Tobetsa mona ho bonts'a lifolakha tsa HAO leqepheng lena mme u lefelle katleho feela

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$100M ho Ntšetsa Pele Kalafo ea Likokoana-hloko tsa Mafu a Mahlo le a Rareng a Ikemetseng

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Dianthus Therapeutics kajeno e phatlalalitse ho phethoa ha lichelete tsa eona tsa $ 100 milione Series A lichelete tse etelletsoeng pele ke 5AM Ventures, Avidity Partners, le Fidelity Management & Research Company, ka ho kenya letsoho ho tsoa ho batseteli ba eketsehileng ho kenyeletsa Wedbush Healthcare Partners le bathehi ba lichelete Fairmount, Tellus BioVentures, le Venrock Healthcare Capital Partners. . Lichelete li tla sebelisoa ho atolosa boetapele le lihlopha tsa saense, ho ntšetsa pele lenaneo la k'hamphani, DNTH103, ho ea tleliniking selemong sena, le ho potlakisa mananeo a eketsehileng a lipeipi bakeng sa batho ba phelang le mafu a matla le a sa tloaelehang a autoimmune. DNTH103 ke anti-monoclonal antibody e matla, ea moloko o latelang e ikemiselitseng ka mokhoa o ikhethileng mofuta o sebetsang oa li-C1 tse tlatselletsang, tse ka khonang ho etsa hore ho be le molumo o tlase oa dosing le tsamaiso e fokolang khafetsa e ntseng e ntlafatsoa ka theknoloji ea ho atolosa halofo ea bophelo. 

Dianthus o boetse a phatlalalitse ho khethoa ha Marino Garcia joalo ka Mopresidente le Ofisiri e ka Sehloohong ea Phethahatso, a kenela ka Pulungoana 2021, le Simrat Randhawa, MD, MBA, joalo ka Ofisiri e ka Sehloohong ea Bongaka. Monghali Garcia, eo e leng setsebi sa khoebo ea khale le setsebi sa maano, o tlisa lilemo tse fetang 25 tsa boiphihlelo ba indasteri ho nts'etsopele ea khoebo le mesebetsi ea boetapele ba ts'ebetso lik'hamphaning tse phahameng tsa biotech le pharma, haufinyane tjena e le Motlatsi e Moholo oa Motlatsi oa Motlatsi, Khoebo le Nts'etsopele ea Khoebo ho Zealand Pharma. Dr. Randhawa o tlisa lilemo tse fetang 20 tsa ts'ebetso ea bongaka le phihlelo ea indasteri ea meriana ho Dianthus, ho kenyelletsa le mesebetsi e phahameng ea boetapele e lebisitsoeng libakeng tsa autoimmune le mafu a sa tloaelehang. Haufinyane tjena o sebelitse e le Motlatsi e Moholo oa Mopresidente oa Litaba tsa Tleliniki le tsa Bongaka Aurinia Pharmaceuticals.

"Re ikemiselitse ho ntlafatsa bophelo ba batho ba phelang le maloetse a matla le a sa tloaelehang a ho itšireletsa mafung 'me re kholisehile hore li-antibodies tsa rona tse khethiloeng li na le monyetla oa ho ba mekhoa ea phekolo e ntle ka ho fetisisa," ho boletse Marino Garcia, Mopresidente le Mookameli oa Phethahatso, Dianthus Therapeutics. "Re motlotlo ho ba le sehlopha se matla sa bo-ramatsete ba etelletseng pele ba theknoloji ea baeloji, litho tse nang le boiphihlelo ba Boto, le baetapele ba hloahloa le bo-ramahlale ha re ntse re ntšetsa pele motlatsi oa rona tleliniking hamorao selemong sena, ho nts'etsapele liphaephe tsa rona tsa ho sibolla, le ho holisa sehlopha sa rona likhoeling tse tlang. . Dianthus e boemong ba ho ba k'hamphani e tlatselletsang e etellang pele, e tataisoang ke kutloisiso e tebileng ea litlhoko tsa bakuli. ”

Dianthus e sebelisa matla a ho khetha litseleng tse tlatselletsang ho theha li-antibodies tse matla tsa monoclonal tse nang le bokhoni ba ho hlola mefokolo ea litlhare tse tlatselletsang hona joale. Ho fapana le litlhare tsa morao-rao tsa li-antibody tse tlamang ho liprotheine tse tlatselletsang tse sa sebetseng le tse sebetsang, DNTH103 e khetha feela mofuta o sebetsang oa li-C1s tse tlatselletsang protheine, e nolofalletsang molumo o tlase oa dosing le tsamaiso e fokolang khafetsa. Theknoloji ea eona ea ho atolosa halofo ea bophelo e boetse e fokotsa ho feta makhetlo a dosing. Ka litšoaneleho tsena tse fapaneng le ho thibela matla a matla a C1s, DNTH103 e etselitsoe ho imolla moroalo oa boholo bo phahameng, tsamaiso ea khafetsa ka li-infusions tsa IV kapa tse sa thabiseng, hangata tse ka tlas'a letlalo. Ho potlakisa nts'etsopele ea kalafo e bonolo ea subcutaneous e ka ba phetoho ho atoloseng palo ea bakuli ba ka ruang molemo ho tsoa liphekolong tse tlatselletsang, ha ho ntse ho fokotsa mathata le litšitiso tse atileng bophelong ba bakuli kajeno - qetellong ho lumella bakuli ba bangata ho phela bophelo bo botle ka botlalo. bokhoni. 

"Re motlotlo ho ts'ehetsa Dianthus Therapeutics ho nts'etsapele ho sibolloa le nts'etsopele ea li-antibody tsa moloko o tlang, tse matla, le tse fapaneng haholo tsa kalafo," ho boletse Paula Soteropoulos, Motsamaisi oa Boto ea Dianthus le Strategic Advisor ho 5AM Ventures. "Ka boetapele ba Mopresidente le CEO ea sa tsoa khethoa, Marino Garcia, le sehlopha se nang le talenta sa baokameli ba khale ba biotech le bo-rakhoebo ba nang le rekoto e pharalletseng ea katleho, re lebelletse ho bona Dianthus e tlisa liphekolo tsa bona tse ncha ho bakuli ba nang le bothata bo matla le bo sa tloaelehang. mafu a autoimmune.”

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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