Sethethefatsi se secha sa Kankere sa Zantrene se sireletsa pelo lefung

Breakingnewsshow | eTurboNews | eTN

Khamphani ea Australia ea biotech le e nepahetseng ea oncology, Race Oncology, e phatlalalitse katleho ea lipatlisiso tsa pele tse fumaneng hore Zantrene® e khona ho sireletsa lisele tsa mesifa ea pelo lefung ha e ntse e ntlafatsa polao ea lisele tsa mofetše oa matsoele ha e sebelisoa hammoho le anthracycline, doxorubicin.

  • Sethethefatsi sa Race Oncology Zantrene se bonts'itsoeng ho sireletsa lisele tsa mesifa ea pelo ea motho lefung la chemotherapy le bakoang ke anthracycline. Anthracycline's ke lithethefatsi tse thibelang mofetše ka ho fetisisa tse sebelisoang ka ho fetesisa, leha ho le joalo li ka baka tšenyo e mpe ea pelo. 
  • Patlisiso ea pele ho kliniki e boetse e bonts'itse bokhoni ba Zantrene ba ho sebelisana le li-anthracycline tse teng ho bolaea lisele tsa mofetše oa matsoele hamolemo. 
  • Ka lebaka la bohlokoa ba ho sibolloa, Zantrene e tla potlakisoa tleliniking ka teko ea Phase 2b e reriloeng bakeng sa 2022 ho bakuli ba mofetše oa matsoele ba kotsing e kholo ea tšenyo ea pelo e bakiloeng ke anthracycline. 
  • E fana ka menyetla ea litefello tsa bongaka le tsa khoebo tsa khale tse tsoang mefuteng e mecha ea Zantrene/anthracycline le metsoako.

Lena ke lekhetlo la pele sethethefatsi se bonts'a bokhoni ba ho lebisa mofetše le ho sireletsa pelo tšenyo ea anthracycline. Ho sibolloa hona ho fana ka tšepo e ncha ho bakuli ba limilione ba mofets'e lefatšeng ka bophara ba fumanang kalafo ea lik'hemik'hale ka li-anthracyclines 'me ba kotsing ea ho senyeha ho tebileng le ho sa feleng lipelong tsa bona. 

Li-anthracycline li tsejoa ka ho pharaletseng e le phekolo e sebetsang ka ho fetisisa ea ho thibela kankere e kileng ea etsoa 'me e sebelisoa mefuteng e mengata ea kankere ho feta sehlopha leha e le sefe sa anti-cancer.[1], ho akarelletsa leukemias, lymphomas, neuroblastoma, liphio, sebete, mpa, popelo, qoqotho, mahe a bomme, sarcoma, senya, kankere ea matšoafo le ea matsoele. Leha ho le joalo, ho tšaba liphello tse kotsi tsa anthracycline pelong ho lebisitse ho litsebi tse ngata tsa oncology ho fokotsa tšebeliso ea tsona ea meriana ena e sebetsang ka ho fetisisa. Ho sibolloa ha Race ho na le monyetla oa ho fetola ts'ebeliso ea li-anthracycline ka ho lumella lingaka tsa oncologists ho sebelisa lithethefatsi tsena tse matla ho fihlela matla a tsona a ho thibela mofetše ntle le ho tšaba ho senyeha ho sa feleng pelong.

The Zantrene® Lenaneo la ho etsa lipatlisiso ka polokeho ea pelo le etelletsoe pele ke bafuputsi ba hlahelletseng ba lefu la pelo, Baprofesa ba Kopanetsoeng Aaron Sverdlov le Doan Ngo, ka tšebelisano le rasaense oa mofets'e oa Motlatsi oa Moprofesa Nikki Verrills, Univesithing ea Newcastle.

Moprofesara Aaron Sverdlov o itse: “Ho fihla joale, mohopolo oa liphekolo tse ka bang teng tsa mofets'e eseng feela tseo e seng tsa cardiotoxic empa, ha e le hantle, cardio-protective ha e so hlahlojoe kapa hona ho natefeloa, haholo-holo ka lebaka la 'mekhoa e khethehileng ea lefu tlhokomelong ea bophelo. Liphetho tsa rona li fana ka maikutlo a hore Zantrene, moriana o thibelang mofetše, ka nako e tšoanang e ka fana ka tšireletso khahlano le litlamorao tse chefo pelong ho tsoa ho e 'ngoe ea li-agent tse sebelisoang haholo tsa chemotherapy, doxorubicin. Bona ke bopaki ba pele ba mofuta oa eona ho bonts'a hore ho na le kalafo eo ka bobeli e shebaneng le mofetše le ho sireletsa pelo! Sena se na le monyetla oa ho ntlafatsa liphetho tsa bophelo bo botle ho bakuli ba bangata ba mofetše le baphonyohi ka ho ntlafatsa kalafo ea bona ea mofetše ha ba ntse ba thibela nts'etsopele ea lefu la pelo. ”

Leha ena e le tšibollo e ncha e thabisang, Zantrene® (bisantrene dihydrochloride) e na le nalane e telele ea bongaka, esale e ntlafalitsoe lilemong tsa bo-1970 e le mokhoa o sireletsehileng oa pelo ho feta li-anthracyclines[2] pele ho tumello Fora lilemong tsa bo-1990. Leha polokeho ea pelo e ntlafalitsoeng ea Zantrene e netefalitsoe litekong tse fetang 50 tsa bongaka[3], , potso ea hore na Zantrene e ka thusa ho thibela tšenyo ea pelo e bakoang ke anthracyclines ha ho mohla e kileng ea rarolloa.

Ha a bua ka liphetho tse ncha tsa lipatlisiso, Ofisiri e ka Sehloohong ea Saense ea Race, Ngaka Daniel Tillett o itse: “Ho fumana hore Zantrene e ka sireletsa pelo ho tsoa ho chemotherapy ha e ntse e bolaea mofetše hamolemonyana ke sephetho se makatsang sa 'mafatše ka bobeli'. Kaha li-anthracycline li sebelisoa ho bakuli ba limilione ba mofetše selemo se seng le se seng, ho thata ho fetelletsa bokhoni ba kliniki le khoebo ea katleho ena!”

Nahanisisa

  • Moetsong ona oa preclinical, Zantrene e sireletsa lisele tsa mesifa ea pelo hore li se ke tsa senyeha ke doxorubicin ha e ntse e sebelisana le li-anthracyclines ho bolaea lisele tsa mofetše oa matsoele hamolemo. 
  • Race e kentse kopo ea patent e sebetsanang le motsoako oa Zantrene le anthracycline bakeng sa ts'ireletso ea pelo ea bakuli. Patent ena (haeba e fanoe) e tla fana ka tšireletso ea motsoako oa lithethefatsi le ts'ebeliso ea ona ea bongaka ho fihlela 2041. 
  • Tšibollo ena e ncha ea tšireletso ea pelo e tla fetisetsoa tleliniking ka potlako. Nalane e pharalletseng ea bongaka ea Zantrene e lumella motsoako ona hore o tsoele pele kapele ho tsa bongaka. 
  • Lipuisano tse tsoetseng pele li ntse li tsoela pele le lingaka tsa Australia ho tsamaisa teko ea meriana ea Phase 2b ho bakuli ba kankere ea matsoele ba kotsing e kholo ea ho senyeha ha pelo e bakoang ke anthracycline. 
  • Tšibollo ena e bula menyetla e mecha ea 'maraka bakeng sa Zantrene ea menyetla e tšoanang ea bongaka le ea khoebo ho tšibollo ea pejana ea hore Zantrene ke inhibitor e matla ea FTO.

Mehato e latelang

  • Lithuto tsa liphoofolo li tla tsamaisoa ho Q4 CY2021/ Q1CY2022. 
  • Lithuto tse ling tsa pele ho kliniki ho etsa lipatlisiso tsa hore na Zantrene e ka sireletsa pelo ho tsoa tšenyong ke litlhare tse ling tsa chemotherapeutic tse tsejoang hape ka ho baka tšenyo ea pelo. 
  • Lithuto tse ling tsa ho fumana mokhoa oa limolek'hule oa ts'ebetso ea Zantrene e sireletsang pelo. Sena se ka lumella ho tsebahatsa mesebetsi e meng ea tšireletso ea Zantrene. 
  • Nts'etsopele ea metsoako e mecha le e ntlafalitsoeng ea motsoako oa lithethefatsi ka boleng bo ntlafalitsoeng ba bongaka le khoebo. 
  • Ho qalisoa ha teko ea kliniki ea mofetše oa matsoele oa Phase 2b ka 2022.

Mabapi le mongoli

Avatar ea Juergen T Steinmetz

Mokha oa Juergen T Steinmetz

Juergen Thomas Steinmetz esale a sebetsa indastering ea maeto le ea bohahlauli ho tloha ha a le lilemong tsa bocha Jeremane (1977).
O thehile eTurboNews ka 1999 e le leselinyana la pele le fumanehang marang-rang bakeng sa indasteri ea bohahlauli ea maeto a lefats'e.

Subscribe
Tsebiso ea
moeti
0 Comments
Li-feed tsa marang-rang
Sheba maikutlo ohle
0
Ke rata maikutlo a hau, ka kopo fana ka maikutlo.x
()
x
Arolelana ho...