Phekolo e Ncha e ka Liehisa Tsoelo-pele ea Lefu la Alzheimer

Moleac o phatlalalitse ho lokolloa ha liphetho tsa thuto ea ATHENE, e hatisitsoeng ho Journal of the American Medical Director Association (JAMDA).

Liphekolo tse ka liehisang lefu la AD ha e se e fihlile boemong ba bongaka, e ntse e le tlhoko ea bohlokoa ea bongaka e sa finyelloang. NeuroAiD™II e bonts'itse hore e na le litlamorao tsa modulatory ho amyloid precursor protein (APP) process2 le phetoho ea protheine ea tau hore e be mefuta e sa tloaelehang ea phosphorylated le aggregated3, hammoho le neuro-regenerative le neuro-restorative properties4. Litlamorao tse ntle tsa NeuroAiD™II mabapi le ts'ebetso ea kelello e sa sebetseng e se e bonts'itsoe kotsi e sithabetsang ea boko5.

Therapy ea lefu la Alzheimer le NEuoaid (ATHENE) Thuto ke thuto ea pele ea ho lekola polokeho le katleho ea NeuroAiD™II ho bakuli ba AD ba bonolo ho isa ho ba itekanetseng ba tsitsitseng liphekolong tse tloaelehileng tsa matšoao.

ATHENE e ne e le teko ea likhoeli tse 6 e sa boneng habeli, e laoloang ke placebo e lateloa ke katoloso e bulehileng ea kalafo ea NeuroAiD™II bakeng sa likhoeli tse ling tsa 6. Lihlooho tsa 125 tse tsoang Singapore li ne li kenyelelitsoe tekong, e neng e kopantsoe ke Setsi sa Memory Aging le Cognition, National University Health System, National Neuroscience Institute, le Sepetlele sa St. Luke, Singapore.

• NeuroAiD™II e bontšitse tšireletseho ea nako e telele e le phekolo ea tlatsetso ho AD ntle le keketseho ea bakuli ba nang le liketsahalo tse mpe tse tebileng kapa liketsahalo tse mpe.

• Ho qalisoa ha NeuroAiD™II pele ho nako ho fane ka ntlafatso ea nako e telele ea kutloisiso ha e bapisoa le placebo (sehlopha se qalang morao-rao) se lekantsoeng ke ADAS-cog, ka lipalo-palo ka likhoeli tsa 9, le ho fokotsa ho theoha ha nako.

Liphetho tsa thuto ea ATHENE li tšehetsa molemo oa NeuroAiD™II e le phekolo e sireletsehileng ea ho eketsa phekolo ea phekolo ea AD kaha thuto ha e fumane bopaki ba keketseho e kholo ea liketsahalo tse mpe pakeng tsa MLC901 le placebo. Liphuputso li fana ka maikutlo a bokhoni ba MLC901 ba ho fokotsa tsoelo-pele ea AD e tsamaellanang le lithuto tsa pele tsa bongaka le tsa bongaka tse phatlalalitsoeng, e leng se etsang hore e be phekolo e tšepisang ho bakuli ba AD. Liphetho tsena li hloka netefatso e eketsehileng lithutong tse kholoanyane le tse telele.                                                         

Lentsoe le tsoang ho Mofuputsi e Moholo

"Lefu la Alzheimer ke sesosa se atileng haholo sa 'dementia', se ikarabellang bakeng sa 60-80% ea linyeoe. Ho fihlela tumello ea morao-rao ea aducanumab ke FDA, ho ne ho se na phekolo ea ho fetola lefu bakeng sa Lefu la Alzheimer, 'me phekolo ea matšoao e teng hona joale e batla ho lieha ka nakoana ho mpefala ha matšoao a' dementia 'me ho ntlafatsa boleng ba bophelo ho ba nang le lefu la Alzheimer's le bahlokomeli ba bona. Kahoo, hoa hlokahala ho fa bakuli le bahlokomeli ba bona monyetla oa ho fumana tlhahlobo le kalafo e ncha.

Liphetho tse ts'episang tsa phuputso ea ATHENE li lokela ho utloisisoa e le karolo ea phetoho ea phaephe ea nts'etsopele ea lithethefatsi ea Alzheimer's ho tloha matšoao ho ea ho liphekolo tse fetolang mafu. Phuputso ena le liphekolo tse ling tse ka bang teng li lokela ho hlahlobjoa ka matla ke liteko tsa bongaka tse entsoeng hantle. ”

Moprofesa Christopher Chen

Motsamaisi, Setsi sa Memory Botsofali le Cognition, Sisteme ea Bophelo ea Univesithi ea Sechaba le Moprofesa oa Motlatsi, Lefapha la Pharmacology, Sekolo sa Bongaka sa Yong Loo Lin, Univesithi ea Sechaba ea Singapore.

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