Teko e Ncha ea Kliniki bakeng sa Kankere ea Metastatic Castration-Resistant Prostate

ngotsoeng ke mohlophisi

ESSA Pharma Inc., k'hamphani ea meriana ea boemo ba bongaka e shebaneng le ho nts'etsapele liphekolo tse ncha tsa kalafo ea mofetše oa senya, kajeno e phatlalalitse mokuli oa pele ea kentsoeng thutong e tšehelitsoeng ke Khampani ea Phase 1/2 ho lekola polokeho, mamello le katleho ea pele ea ESSA. Epi-7386, e leng N-terminal domain androgen receptor inhibitor ea boemo ba pele, hammoho le Astellas Pharma Inc.'s le Pfizer Inc.'s ligand-binding domain androgen receptor inhibitor, enzalutamide, ho bakuli ba nang le lefu la tsoekere. kankere ea tšoelesa ea senya e hanyetsanang le metastatic castration.

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"Ho qalisoa ha teko ena ea motsoako le Astellas ke nako ea metsi bakeng sa ESSA ha re ntse re batlisisa melemo e ka 'nang ea e-ba teng ea kliniki ea ho thibela receptor ea androgen ka litsela tse peli tse ikemetseng tsa phekolo ea bakuli ba nang le mCRPC ba e-s'o fumane phekolo ka antiandrogen ea moloko oa bobeli. lithethefatsi,” ho boletse Dr. David. R. Parkinson, Mookameli ea ka Sehloohong, ESSA Pharma Inc. "Ho kopanya liphekolo tsa rona tse peli ka nako e le 'ngoe ho tla lebisa lipheletsong tse peli tsa receptor ea androgen. Mehlala ea preclinical, re bone hore ho kopanya EPI-7386 le li-antiandrogens tsa hona joale ho ka lebisa ho thibelo e tebileng le e pharaletseng ea biology ea androgen. Teko ena ea Phase 1/2 e tšoaea lekhetlo la pele letotong la lithuto tsa kliniki ho lekola EPI-7386 hammoho le litlhare tsa morao-rao tsa antiandrogen ho bakuli ba nang le mCRPC, ka liteko tse ling tse kopaneng tsa Phase 1/2 tse lebelletsoeng ho qala ka 2022.

Teko ea bongaka ea Phase 1/2 (NCT05075577) e qala ka karolo ea pele eo ho eona litekanyetso tsa moriana ka mong li lokisoang li lateloa ke karolo ea 1 moo moemeli a le mong enzalutamide a bapisoang le motsoako oa enzalutamide le EPI-2. Phuputso ea karolo ea 7386 e lebeletsoe hore e ngolise bakuli ba 1 mCRPC ba e-s'o phekoloe ka mekhoa ea phekolo ea antiandrogen ea moloko oa bobeli. Sepheo sa karolo ea 30 ea thuto ke ho lekola polokeho le mamello ea motsoako oa lithethefatsi le ho theha litekanyetso tse khothaletsoang tsa mohato oa 1 bakeng sa EPI-2 le enzalutamide ha li kopantsoe hammoho. Thuto ea mohato oa 7386 e lebeletsoe ho ngolisa bakuli ba 2 mCRPC ba e-s'o phekoloe ka mekhoa ea phekolo ea antiandrogen ea moloko oa bobeli. Sepheo sa karolo ea 120 ea thuto ke ho hlahloba polokeho, mamello le ts'ebetso ea antitumor ea EPI-2 hammoho le tekanyo e tsitsitseng ea enzalutamide ha e bapisoa le enzalutamide e le moemeli a le mong.

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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