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Metsoako e Ncha e Tšepisang ea Anticancer

ngotsoeng ke mohlophisi

Kankere ke e 'ngoe ea lisosa tse ka sehloohong tsa lefu linaheng tse ngata 'me e ntse e tsoela pele ho ba moroalo o moholo sechabeng. E 'ngoe ea liphephetso tse ka sehloohong tsa ho hlahisa mekhoa ea phekolo ho loantša lefu lena le bolaeang ke hore lithethefatsi li lokela ho lebisa lisele tsa mofetše ka ho khetheha 'me li be le litla-morao tse fokolang kamoo ho ka khonehang. Har'a metsoako e mengata e ntseng e ithutoa hajoale, motsoako oa boron dipyrromethene (BODIPY) le metal-organic macrocycles (MOCs) le metal-organic frameworks (MOFs) e bonts'a bokhoni bo boholo eseng feela ho loants'a mofets'e ka katleho, empa le ho thusa bafuputsi ho utloisisa lefu le betere.   

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Sengoliloeng sa morao-rao sa tlhahlobo se phatlalalitsoeng ho Coordination Chemistry Reviews, sehlopha sa bo-rasaense ba etelletsoeng pele ke Moprofesa Chang Yeon Lee le Gajendra Gupta oa Univesithi ea Naha ea Incheon, Korea, ba buisane ka ho iphetola ha lintho le tsoelo-pele ea morao-rao lefapheng la li-MOC le li-MOF tse thehiloeng ho BODIPY, ka tsepamisa maikutlo mesebetsing e ka bang teng ea metsoako e le lithethefatsi tse thibelang mofetše le lisebelisoa tsa lipatlisiso tsa mofetše. Sengoliloeng se hlalosa melemo le likamano tse fapaneng tsa metsoako le mekhoa e meng ea bongaka hape e bua ka litšitiso tse kholo ts'ebelisong ea tsona e atileng.

Joale, lisebelisoa tsee ke eng, 'me ke eng e etsang hore li kopane hantle? Li-MOC le li-MOF ke li-complexes tsa tšepe tse sebetsang e le sethala se feto-fetohang moo mesebetsi e mecha e ka hlahisoang habonolo ka liphetoho. Ka bobeli li sebelisoa haholo ho biomedicine mme li bonts'itse bokhoni e le li-anticancer agents tse nang le khetho e ntle. Leha ho le joalo, ha BODIPY e sebelisoa ho li-MOC kapa li-MOF, thepa ea photophysical ea motsoako o hlahisoang e ka hlophisoa hantle ho finyella liphello tse fapaneng.

Ntlha ea pele, li-complexes tse thehiloeng ho BODIPY ke li-photosensitizing agents tse ntle bakeng sa phekolo ea photodynamic, eo ho eona moriana o sebelisoang ke khanya ho senya lisele tse lebisitsoeng. Ha li kopantsoe le li-MOC kapa li-MOF, katleho ea li-complexes tsena ha litlhare tse thibelang mofetše li eketseha. Ea bobeli, li-complexes tse thehiloeng ho BODIPY li na le maikutlo a acidity (pH) ea bohareng. Hobane lihlahala tse ling tse kotsi li na le pH e tlase (e nang le asiti), metsoako ena e ka ntlafatsoa le ho feta e le hore e tobane le lisele tse nang le mofetše 'meleng ka ho sebelisa mochine ona hampe. Qetellong, empa ha e le hantle, thepa ea fluorescent ea li-MOC le li-MOF li ka hlophisoa e le hore boemo ba tsona ka har'a lisele bo ka lateloa habonolo ho sebelisoa mekhoa ea microscopy ea fluorescence. "Ho ba bonolo haholo ho fumana lithethefatsi tse thehiloeng ho BODIPY-based MOC / MOF ka har'a lisele tsa mofetše tse phekoloang li tla thusa litsebi tsa limolek'hule le lisele ho utloisisa mekhoa ea liketso tsa limolek'hule tsena khahlanong le kankere," ho hlalosa Prof. Lee.

Leha ho na le mefokolo e meng ea li-MOC/MOF tse thehiloeng ho BODIPY, joalo ka motsoako o jang nako le kutloisiso ea rona e sa phethahalang ea chefo ea eona, metsoako ena e ka ba libapali tsa bohlokoa ntoeng ea rona khahlano le mofetše. "Li-MOC le li-MOF tse entsoeng ka BODIPY li na le likarolo tsohle tsa bohlokoa tse hlokahalang hore motho e be moemeli ea loketseng oa lithethefatsi tse thibelang mofetše," ho phethela Prof. Gupta. Etsa bonnete ba hore u lula u shebile limolek'hule tsena tse tsoetseng pele le limakatso tseo li ka li tlisang lefats'eng la kalafo ea mofets'e le lipatlisiso.

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Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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