Boithuto ba Phase I bo ile ba etsoa ho bakuli ba lilemo tse 45-80 ba ileng ba ts'oaroa ke stroke se matla sa ischemic. Mali a mokhubu a fumanoe ho tsoa lethathamong la mali la StemCyte la sechaba le thehiloeng ho mofuta oa mali oa ABO/Rh, papali ea Human Leukocyte Antigen (HLA) ea> 4/6, le tekanyo ea sele ea palo eohle ea mononuclear cell (MNC) ea 0.5-5 x 107 lisele / kg. Ho feta moo, litekanyetso tse 'nè (4) 100 ml tsa mannitol li ile tsa kenngoa methapong metsotso e 30 ka mor'a ho kenngoa mali ka mokhubu le lihora tse ling le tse ling tse 4 ka mor'a moo.
Liphello tsa mantlha e bile palo ea bakuli ba ileng ba hlaolela lefu la graft versus host (GVHD) matsatsing a 100 ka mor'a tšelo ea mali. Liphetho tsa bobeli e bile liphetoho ho National Institutes of Health Stroke Scale (NIHSS), index ea Barthel, le lintlha tsa Berg Balance Scale. Ketsahalong e 'ngoe, mokuli e motona ea lilemo li 46 ea nang le nalane ea khatello ea mali le hemodialysis bakeng sa lefu la renal la ho qetela o ile a phekoloa ka mokhoa o fapaneng a sebelisa hUCB e nang le ABO / Rh e tšoanang, papali ea 6/6 HLA, le palo ea MNC ea 2.63 x 108 lisele/kg. Mokuli ha aa ka a hlahisa liketsahalo tse mpe tse tebileng kapa GVHD nakong ea thuto ea likhoeli tsa 12. Lintlha tsa hae tsa NIHSS li fokotsehile ho tloha ho 9 ho ea ho 1; palo ea Berg Balance Scale e eketsehile ho tloha 0 ho ea 48, 'me palo ea index ea Barthel e eketsehile ho tloha 0 ho ea ho 90. Phuputso ena ea pele e bontšitse hore mokuli e moholo ea nang le hemiplegia ka lebaka la ho otloa ke ischemic o ile a hlaphoheloa ka ho feletseng nakong ea likhoeli tsa 12 ka mor'a ho fumana phekolo ea UCB ea allgeneic.
"Re thabile haholo ka liphello tse atlehileng tsa kliniki tsa thuto ea StemCyte's Phase I," ho boletse Mopresidente oa StemCyte le Molula-setulo Jonas Wang, PhD. "Kaha lefu la stroke le le matla e le sesosa sa bobeli le sa boraro se bakang lefu le bokooa, ka ho latellana, lefatšeng ka bophara, phello ena e tsoteha joalokaha e ne e sa lebelloa." Hoo e ka bang 30% -35% ea batho ba nang le lefu la stroke ba shoa 'me hoo e ka bang 75% ea baphonyohi ba na le bokooa bo sa feleng. Liphekolo tsa morao-rao tse maemong a hlobaetsang li kenyelletsa tšebeliso ea li-thrombolytic, anticoagulant le li-antiplatelet agents. Leha ho le joalo, tšebeliso ea mahlahana a joalo e eketsa sekhahla sa ho tsoa mali ka 15% -20%.
Lisele tsa methapo ea mali li ata ho ba lisele tsa methapo ea kutlo, 'me li ile tsa fumanoa li sebetsa hantle kalafong ea mafu a' maloa a neurodegenerative. Ka lefu la boko, ho kenngoa ka methapo ea UCB le MNCs ho ka tsosolosa bokhoni ba boikoetliso hammoho le ho fana ka liphello tsa neuroprotective joalokaha ho bontšoa ke ho fokotseha ha pontšo ea matšoao a ho ruruha a kang TNF-alpha, IL-1β le IL-2.
