LUMICKS, k'hamphani ea lisebelisoa tsa mahlale a bophelo e nts'etsang lisebelisoa bakeng sa tlhahlobo e matla ea molek'hule e le 'ngoe le tlhahlobo ea matla a lisele, kajeno e phatlalalitse hore pampiri e senolang lintlha tse ncha mabapi le ts'ebetso ea cell ea Chimeric Antigen Receptor (CAR) T e phatlalalitsoe khatisong ea Pherekhong 2022 ea Frontiers in Immunology. Pampiri ena e hlalosa lipatlisiso tse ncha tse entsoeng Kings College London tlas'a thuso ea Dr. John Maher, ka ts'ebelisano le Leucid Bio, ho sebelisa LUMICKS 'z-Movi® Cell Avidity Analyzer. Patlisiso ena e ncha e fana ka maikutlo a hore ho kenyelletsa receptor ea bobeli e lebisitsoeng ho lisele tsa CAR T ho ntlafatsa bokhoni ba bona ba ho lebisa liseleng tsa mofetše mme ho bonts'a ts'episo ea ho ntlafatsa li-immunotherapies tsa mofets'e mefuteng ea pele ho tleliniki.
Ho boletse Dr. John Maher, Morupeli e Moholo oa Kings College London Sekolong sa Kankere le Saense ea Meriana, le Ofisiri e ka Sehloohong ea Saense ea Leucid Bio, "Bokhoni bo ikhethang ba z-Movi Cell Avidity Analyzer bo ile ba re nolofalletsa ho lekanya matla a feletseng a ho sebelisana. pakeng tsa sehlopha sa rona sa lisele tsa CAR T le lisele tsa mofetše. Ka ho sebelisa sesebelisoa sa LUMICKS'z-Movi, re ka fumana habonolo li-CAR tsa 'goldilocks' tse sa tlanngoeng ka matla haholo kapa tse fokolang haholo ho lisele tse lebisitsoeng 'me li bonts'a polao e phahameng ho mefuta ea pele ho tleliniki. Lintlha tse ncha tse fumanoeng ho sebelisoa litekanyo tsa matla a lisele li ka thusa haholo ho ntlafatsa tsela eo re qapang liphekolo tsa lisele.
Andrea Candelli, Ofisiri e ka Sehloohong ea Saense ea LUMICKS, "Re arolelana thabo ea sehlopha sa Kings College mabapi le bopaki bo eketsehileng bo bontšitsoeng ke pampiri ena mabapi le karolo ea bohlokoa eo matla a lisele a e bapalang ho utulla le ho ntlafatsa lisele tsa CAR T. Patlisiso e matla ea Dr. Maher e totobatsa lintlha tseo theknoloji ea rona ea phetoho e ka thusang bafuputsi lefatšeng ka bophara ho li sibolla, le ho thusa mahlale ho rarolla mathata a mantlha bophelong ba batho, haholoholo mabapi le ho rala mekhoa ea ho itšireletsa mafung e ka bang matla ho loants'a mofetše.
CAR-T cell immunotherapies e fetola lisele tsa T tsamaisong ea 'mele ea ho itšireletsa mafung ho lebisa le ho senya lisele tsa mofetše ka ho fetola liphatsa tsa lefutso lisele tsa T ho etsa protheine ea CAR, eo lisele tsa T li tlamang ho eona, le ho hlasela lisele tsa kankere. Mekhoa e joalo ea phekolo e fanoa e le phekolo ea kankere e itseng 'me bafuputsi ba bangata, ho akarelletsa le Dr. Maher, ba ntse ba etsa lipatlisiso ka meralo e mecha ea phekolo ea CAR T-cell bakeng sa kankere e tiileng ea hlahala.
Z-Movi e lekanya ho cheseha, kapa boemo ba ho tlama, lipakeng tsa lisele tsa 'mele tsa ho itšireletsa mafung joalo ka CAR Ts, le liphofu tsa bona, lisele tsa mofetše, tse nolofalletsang bafuputsi ho tseba lisele tse matla ka ho fetesisa tsa immunotherapeutic e le bakhethoa ho lebisa le ho senya lisele tse itseng tsa mofetše. Theknoloji ena e ncha e fana ka liphetho tse boletsoeng esale pele, tse ka hlahisoang hape, le tse potlakileng ho qeto ea sele e le 'ngoe ntle le ho senya ts'ebetso ea lisele, hape e netefatsa ho ts'oaroa ka mokhoa o bolokehileng oa sampole. Litharollo tsa "cell avidity" tsa LUMICKS li sebelisa li-acoustics ho lekanya matla le tšebelisano lipakeng tsa lisele, ka sepheo sa ho khutsufatsa potoloho ea nts'etsopele ea lithethefatsi bakeng sa kalafo ea lisele tse amohelang le li-immunotherapies tse ling le ho fokotsa sekhahla sa ho hloleha litekong tsa bongaka. E qalileng ho hlahisoa ka 2020, z-Movi e fumane boipiletso bo pharaletseng lilaboratoring tsa thuto le biopharma lefatšeng ka bophara, ka thekiso e potlakileng ea thekiso ka 2021.
