Ka ho senola sebopeho sa protheine e sebelisoang ke baktheria ho pompa lithibela-mafu, sehlopha sa bafuputsi se ile sa qapa mokhoa oa ho phekola oa pele o senyang pompo le ho khutlisetsa matla a lithibela-mafu.
E etelletsoe pele ke bafuputsi ba Univesithi ea New York, Sekolo sa Bongaka sa NYU Grossman, le Setsi sa Kankere sa Laura le Isaac Perlmutter sa NYU Langone, thuto e ncha e sebelisitse microscopy e tsoetseng pele ho "bona" ka lekhetlo la pele sebopeho sa NorA, protheine eo mofuta oa baktheria Staphylococcus. aureus e sebelisa ho pompa lithibela-mafu tse sebelisoang haholo pele li ka li bolaea.
Lipompo tsa Efflux li emela mokhoa o le mong oo S. aureus e fetohileng ho hanyetsa fluoroquinolones, sehlopha sa lithibela-mafu tse amohetsoeng tse fetang 60 tse kenyelletsang norfloxacin (Noroxin), levofloxacin (Levaquin), le ciprofloxacin (Cipro). Fluoroquinolones ha e sa sebetsa khahlano le mefuta e meng ea baktheria e hananang le lithethefatsi, ho kenyelletsa le methicillin-resistance S. aureus (MRSA), sesosa se seholo sa lefu har'a bakuli ba sepetlele ha ts'oaetso e ba matla, bafuputsi ba re. Ka lebaka lena, tšimo e batlile ho qapa li-efflux pump inhibitors, empa liteko tsa pele li sitisitsoe ke litla-morao.
"Ho e-na le ho leka ho fumana lithibela-mafu tse ncha, re tšepa ho etsa lithibela-mafu tse sebelisoang ka ho fetisisa lilemong tse mashome a seng makae tse fetileng, tse sa sebetseng ka lebaka la ho hanyetsa baktheria, tse sebetsang haholo hape," ho bolela sengoli sa thuto ea pele Doug Brawley, PhD. O ile a qeta thuto ea hae ea bongaka lilaboratoring tsa bangoli ba phahameng Nate Traaseth, PhD, moprofesa Lefapheng la Chemistry Univesithing ea New York, le Da-Neng Wang, PhD, moprofesa Lefapheng la Cell Biology ho NYU Grossman School of Medicine. .
SEO U LOKELANG HO SE NKA HO SEHLOOHO ENA:
- He completed his doctoral thesis in the laboratories of senior authors Nate Traaseth, PhD, a professor in the Department of Chemistry at New York University, and Da-Neng Wang, PhD, a professor in the Department of Cell Biology at NYU Grossman School of Medicine.
- Ka ho senola sebopeho sa protheine e sebelisoang ke baktheria ho pompa lithibela-mafu, sehlopha sa bafuputsi se ile sa qapa mokhoa oa ho phekola oa pele o senyang pompo le ho khutlisetsa matla a lithibela-mafu.
- “Instead of trying to find a new antibiotic, we hope to make the most widely used antibiotics over the last few decades, rendered ineffective by bacterial resistance, highly effective again,”.
