Entrinsic Bioscience (EBS) e phatlalalitse sesebelisoa sa ho lekanya peristalsis ea mala e ka lebisang ho nts'etsopele ea lisebelisoa tsa phekolo bakeng sa ho patoa, ho akarelletsa le Irritable Bowel Syndrome-Constipation (IBS-C). Mofuputsi oa Univesithi ea Florida Dr. Sadasivan Vidyasagar, mothehi le molula-setulo oa boto ea boeletsi ba saense ea k'hamphani, haufinyane o ile a arolelana sesebelisoa sa ho lekanya peristalsis hantle le ho sebelisana ha khatello ea intraluminal, ho fokotseha ha mesifa, le liphetoho tsa molumo oa mokelikeli sebokeng sa Experimental Biology 2022 se neng se tšoaretsoe Philadelphia.
Peristalsis ke ts'ebetso e kopanetsoeng ea mesifa ea mala e tsamaisang lijo ka lesapo la mala. Leha e se e ithutoe haholo, tlhahlobo ea boleng ba peristaltic propulsion ha e utloisisoe ka botlalo hobane ha ho sesebelisoa se hlakileng se teng. Ho haella ha sesebelisoa ho na le tšibollo e fokolang ea lithethefatsi tšimong ea ho patoa, ho kenyelletsa le IBS-C.
Vidyasagar le sehlopha sa hae, se neng se kenyelletsa bafuputsi ba UF le Entrinsic Bioscience, ba sebelisitse mabone a tataisoang, litšoantšo tsa masimong hammoho le lirekoto tsa khatello ho lekanya ts'ebetso ea peristaltic.
Stephen J Gatto, molula-setulo le CEO oa Entrinsic Bioscience, o ile a thoholetsa Anusree Sasidharan le sehlopha kaofela sa Ngaka Vidyasagar bakeng sa boitlamo ba bona bo tsoelang pele ba ho khanna mekhoa e mecha ea ho lekola pampitšana ea mala.
"Tlhahiso ea sehlopha e totobatsa bokhoni ba rona ba ho lekanya peristalsis ea mala hantle le ho rala tsela bakeng sa mekhoa ea kalafo ea nakong e tlang e ka sebetsanang le ho pipitleha ho sa foleng ho bakoang ke opioid hammoho le mokhoa o se nang motheo oa PEG oa ho pipitlela ha bohloko le IBS-C. Ho se tloaelehe ha Gut peristalsis ho bohareng ba mefuta e mengata ea maemo a tloaelehileng a bongaka, joalo ka ho patoa le lefu la ho ruruha ha mala. ”
"Ho khona ho qhekella likarolo tsa GI le ho lekola litlamorao ho ka fetola tsela eo re talimang litaba tsa peristaltic mabapi le ho ts'oaroa ha sephiri / ho monya," Gatto a tsoela pele. "Mekhoa ena e metle, re lebelletse hore e tla lumella nts'etsopele e potlakileng ea liphekolo tsa rona tsa RxAA ho alafa pipitlelano le IBS."
Vidyasagar o boetse a fana ka sets'oants'o sa sesebelisoa sa laboratori ea hae e ntlafalitsoeng ho lekanya peristalsis ea mala hantle le tšebelisano ea khatello ea intraluminal, ho honyela ha mesifa le liphetoho tsa molumo oa mokelikeli.
"Sehlopha sa rona se thehile mokhoa o mocha oa ho utloisisa tšebetso ea peristalsis le gut mucosal. Karolo ea SAA e le RxAAs e bonts'a tšepiso ha re ntse re bula mekhoa ea ho pata ho sa foleng, IBS le mafu a mang a amanang le GI, "ho boletse Dr. William Denman, Moeletsi ea ka Sehloohong oa Bongaka ho Entrinsic Bioscience. "Mosebetsi ona e ntse e le mohato oa pele empa o emetse mohato o moholo ho nts'etsopele ea tharollo ea mafu a 'maloa a tšilo ea lijo."
Entrinsic Bioscience ke qalo ea UF e fumanehang ho UF Innovate | Potlakisa ho Sid Martin Biotech e Alachua. Khampani e nts'etsapele litlhare tsohle tsa tlhaho, tse se nang tsoekere bakeng sa hydration ea bongaka, bophelo bo botle ba mala le bophelo bo botle, ho kula le tlhokomelo ea letlalo.
SEO U LOKELANG HO SE NKA HO SEHLOOHO ENA:
- Sadasivan Vidyasagar, founder and chairman of the company’s scientific advisory board, recently shared a tool to better measure peristalsis and the interactions of intraluminal pressure, muscle contraction, and changes in fluid volume at the Experimental Biology 2022 conference held in Philadelphia.
- Vidyasagar o boetse a fana ka sets'oants'o sa sesebelisoa sa laboratori ea hae e ntlafalitsoeng ho lekanya peristalsis ea mala hantle le tšebelisano ea khatello ea intraluminal, ho honyela ha mesifa le liphetoho tsa molumo oa mokelikeli.
- “The team’s presentation highlights our ability to better measure gut peristalsis and lays out the path for future treatment regimens that can address opioid-induced chronic constipation as well a non-PEG-based approach to acute constipation and IBS-C.
