Kajeno Emmes o phatlalalitse hore lipatlisiso tsa Casimir mabapi le nts'etsopele ea likarete tsa lintlha tsa Duchenne Video Assessment (DVA) li phatlalalitsoe ho PLOS ONE. Emmes o ile a fumana Casimir ka Hlakubele 2022, 'me sehlopha se se se le karolo ea Setsi sa Emmes' Rare Disease Center, Orphan Reach™.
DVA ke nova, tlhahlobo ea sephetho sa kliniki e thehiloeng malapeng e lekanyang boiketlo ba ho tsamaea har'a ba nang le Duchenne muscular dystrophy (DMD) ka ho tsebahatsa mekhoa ea metsamao ea matšeliso. Bahlokomeli ba rekota video ea bakuli ba etsang mesebetsi e itseng ea ho sisinyeha lapeng ba sebelisa sesebelisoa se sireletsehileng sa mehala. Pampiri e hlalosa nts'etsopele ea likarete tsa lintlha tseo litsebi tsa 'mele tse koetlisitsoeng ke DVA li li sebelisang ho fana ka lintlha tsa livideo.
Marielle Contesse oa Casimir, rasaense oa lipatlisiso, e ne e le mongoli ea ka sehloohong, le Mindy Leffler, mothehi-'moho le mopresidente, le Christine McSherry, mothehi-'moho le molaoli ea ka sehloohong, har'a bangoli ba bang.
Pampiri e fetileng ho Muscle & Nerve, e ngotsoeng ke Contesse, Leffler le bafuputsi ba bang ba Casimir, e hlahisitse liphuputso tsa lipatlisiso tse bontšitseng hore DVA ke sesebelisoa se ka tšeptjoang le se sebetsang sa ho lekanya boiketlo ba ho tsamaea e le pontšo ea ho teba ha mafu ho bakuli ba nang le DMD. Pampiri ea morao-rao ho PLOS ONE e qaqisa nts'etsopele ea likarete tsa lintlha tsa DVA.
Pampiri ea PLOS ONE e hlalosa lipatlisiso tsa nts'etsopele ea karete ea lintlha tse entsoeng le litsebi tsa 'mele tse nang le phihlelo e kholo ea ho hlahloba bakuli ba DMD. Bafuputsi ba sebelisitse ts'ebetso ea Delphi e fetotsoeng ka makhetlo a mabeli ho bokella maikutlo a litsebi mabapi le likarete tsa lintlha. Nakong ea ts'ebetso ea Delphi, litsebi tsa 'mele li ile tsa hlahloba likarete tsa lintlha bakeng sa mesebetsi eohle e 15 ea motsamao. Mesebetsi ea motsamao ke lintho tseo bakuli ba tloaetseng ho li etsa lapeng, joalo ka ho tsamaea, ho hloa litepisi, ho apara sekipa le ho ja. Ka mor'a mekhahlelo e 'meli ea tlhahlobo le lintlafatso, sehlopha sa litsebi se tiisitse hore litekanyetso tsa motsamao oa matšeliso tse kenyellelitsoeng likareteng tsa lintlha tsa DVA li ne li utloahala, li na le moelelo, ebile li na le moelelo oa bongaka.
Marielle Contesse o itse: "DVA e fana ka fensetere mabapi le tsela eo bakuli ba nang le Duchenne ba tsamaeang le ho sebetsa ka eona tikolohong ea habo bona," 'me likarete tsa rona tsa lintlha li fana ka mokhoa o tloaelehileng oa litsebi tsa 'mele ho tseba mekhoa ea metsamao ea matšeliso. Boemo ba lapeng bo re lumella ho lekola mefuta e mengata ea metsamao ea letsatsi le letsatsi. E boetse e felisa tlhoko ea hore bakuli le malapa ba tsamaee sebaka se selelele ho ea libakeng tsa liteko tsa bongaka. ”
O boetse a re, "Qetellong, re tšepa hore DVA e tla khona ho bona liphetoho mosebetsing oa mokuli ka nako e khuts'oane ho feta mehato e teng ea sephetho. Sena se ka fokotsa nako eo bakuli ba e qetang ba nka karolo tekong ea bongaka. ”
Motsamaisi e Moholo oa Emmes Dr. Christine Dingivan o hlokometse, "Phuputso ena e fana ka motheo oa ho sebelisa Tlhahlobo ea Video ea Casimir's Duchenne ho atolosa menyetla ea ho khetholla tsoelo-pele ea mafu le mekhoa ea phekolo. Re boetse re khothatsoa ke tšebeliso e ka bang teng ea DVA ho lekola mafu a mang a mesifa le a mitochondrial. ”
SEO U LOKELANG HO SE NKA HO SEHLOOHO ENA:
- Nerve, authored by Contesse, Leffler and other Casimir researchers, presented research findings that demonstrated that the DVA is a reliable and valid tool for measuring ease of movement as an indication of disease severity in patients with DMD.
- After two rounds of review and revisions, the expert panel confirmed that the compensatory movement criteria included in the DVA scorecards were understandable, comprehensive, and clinically meaningful.
- She added, “Ultimately, we hope that the DVA will be able to detect changes in patient function in a shorter period of time than existing outcome measures.
