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Phekolo ea Pele e Amoheletsoeng ea Cytopenic Myelofibrosis

ngotsoeng ke mohlophisi

CTI BioPharma Corp. e phatlalalitse Tsamaiso ea Lijo le Lithethefatsi ea US (FDA) e amohetse VONJO (pacritinib) bakeng sa phekolo ea batho ba baholo ba nang le boemo bo bohareng kapa ba kotsi e ka sehloohong kapa ea bobeli (post-polycythemia vera kapa post-essential thrombocythemia) myelofibrosis e nang le palo ea platelet. ka tlase ho 50 × 109/L. VONJO ke novel oral kinase inhibitor e nang le lintlha tse ikhethang bakeng sa JAK2 le IRAK1, ntle le ho thibela JAK1. Tekanyetso e khothaletsoang ea VONJO ke 200 mg ka molomo habeli ka letsatsi. VONJO ke phekolo ea pele e amohelehang e sebetsanang ka ho khetheha le litlhoko tsa bakuli ba cytopenic myelofibrosis.             

"Kamohelo ea kajeno ea VONJO e theha mokhoa o mocha oa tlhokomelo bakeng sa bakuli ba myelofibrosis ba nang le cytopenic myelofibrosis," ho boletse John Mascarenhas, MD, Motlatsi oa Moprofesa, Medicine, Hematology le Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine e Mount Sinai, New York. . "Myelofibrosis e nang le thrombocytopenia e matla, e hlalosoang e le palo ea platelet ea mali e ka tlaase ho 50 × 109 / L, e bontšitsoe hore e fella ka liphello tse mpe tsa ho phela hammoho le matšoao a fokolisang. Mekhoa e fokolang ea phekolo e entse hore lefu lena e be sebaka sa tlhokahalo e potlakileng ea bongaka. Ke thabetse ho bona hore khetho e ncha, e sebetsang le e sireletsehileng ea kalafo e se e fumaneha bakeng sa bakuli bana. ”

"US, ho na le bakuli ba ka bang 21,000 ba nang le myelofibrosis, karolo ea bobeli ho tse tharo ea bona ba nang le cytopenias (thrombocytopenia kapa anemia), hangata e bakoang ke chefo ea mekhoa e meng ea phekolo e amohelehang. Thrombocytopenia e matla, e hlalosoang e le palo ea liplatelete tsa mali tse ka tlase ho 50 × 109/L, e hlaha karolong e le 'ngoe ho tse tharo ea batho bohle ba myelofibrosis,' me e na le bofokoli bo bobe ka ho khetheha. Ka tumello ea VONJO, re thabetse hore joale re khona ho fana ka phekolo e ncha e amohelehang ka ho khetheha bakeng sa bakuli ba cytopenic myelofibrosis. Re tšehetsoa ka lichelete ka botlalo bakeng sa ho qala khoebo, ho latela likoloto tsa rona le litšebelisano tsa borena le DRI, 'me re lebeletse ho fana ka VONJO, phekolo e ka bang molemo ka ho fetisisa bakeng sa bakuli ba cytopenic myelofibrosis, ho bakuli nakong ea matsatsi a 10, "ho boletse Adam R. Craig. , MD, Ph.D., Mopresidente le Mookameli e Moholo oa CTI Biopharma. “Ke rata ho leboha bakuli, bahlokomeli, basebetsi ba liteko tsa tleliniki le bafuputsi ba entseng hore liteko tsa tleliniki tsa VONJO li khonehe. Ke boetse ke leboha sehlopha sa CTI bakeng sa mosebetsi oa bona o boima le boitelo le ho tsepamisa maikutlo a bona litlhoko tsa bakuli. ”

Tumello e potlakileng e ipapisitse le liphetho tsa katleho ho tsoa thutong ea bohlokoa ea Phase 3 PERSIST-2 ea VONJO ho bakuli ba myelofibrosis (platelet e baloa ka tlase ho kapa e lekana le 100 × 109/L). Bakuli ba ne ba e-na le 1: 1: 1 ho fumana VONJO 200 mg habeli ka letsatsi (BID), VONJO 400 mg hang ka letsatsi (QD) kapa phekolo e fumanehang ka ho fetisisa (BAT). Kalafo ea pele ea JAK2 inhibitor e ne e lumelletsoe. Phuputsong ena, ho sehlopha sa bakuli ba nang le palo ea liplatelete tsa motheo tse ka tlase ho 50 × 109/L ba ileng ba phekoloa ka pacritinib 200 mg BD, 29% ea bakuli ba ne ba fokotsehile bonyane ka 35% ha ba bapisoa le 3% ea bakuli ba fumanang spleen. phekolo e molemo ka ho fetisisa e fumanehang, e neng e akarelletsa ruxolitinib. E le karolo ea tumello e potlakileng, CTI e hlokeha ho hlalosa molemo oa tleliniki tekong ea tiiso. Ho phethahatsa tlhokahalo ena ea kamora tumello, CTI e rera ho phethela teko ea PACIFICA, ka liphetho tse lebelletsoeng bohareng ba 2025.

Litlamorao tse mpe tse atileng haholo (≥20%) tse latelang VONJO 200 mg habeli ka letsatsi e ne e le lets'ollo, thrombocytopenia, ho nyekeloa ke pelo, phokolo ea mali le peripheral edema. Litlamorao tse mpe tse mpe khafetsa (≥3%) tse latelang VONJO 200 mg habeli ka letsatsi e ne e le phokolo ea mali, thrombocytopenia, pneumonia, ho hloleha ha pelo, tsoelo-pele ea mafu, pyrexia le squamous cell carcinoma ea letlalo.

WTM London ea 2022 e tla etsahala ho tloha ka la 7-9 Pulungoana 2022. Ngodisa hona joale!

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Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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