Bakuli ba arabelang hantle kalafong e ncha e sebetsang ea lefu la ulcerative

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Avatar ea Linda Hohnholz
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Bakuli ba nang le lefu la ulcerative colitis (UC) ba nkileng mirikizumab ba fihletse litekanyetso tse phahameng ka ho fetesisa tsa pholiso ea bongaka nakong ea libeke tse 12 ha li bapisoa le bakuli ba nkang placebo thutong ea bohlokoa ea LUCENT-1 Phase 3 ea Eli Lilly. Bakuli ba ileng ba nka mirikizumab le bona ba fihletse lintlafatso tsa lipalo holima lintlha tsa mantlha tsa mantlha ho kenyeletsoa mehato ea kliniki, ea matšoao, ea endoscopic le ea histologic (maemo a lisele tsa lisele), ha a bapisoa le a nkang placebo. Liphetho ho tsoa thutong ea pele ea sehlopha sa Lilly li hlahisoa hoo e batlang e le Kopanong ea bo-17 ea European Crohn's and Colitis Organisation (ECCO), e etsahalang Feb. 16-19, 2022.        

"Batho ba nang le ulcerative colitis ba na le ho ruruha ha mucosal ka har'a kolone, e leng se bakang mali a tsoang ka mokokotlong, ho etela hangata ho ea kamoreng ea ho hlapela le tlhokahalo e potlakileng ea ho ntša mala," ho boletse Geert D'Haens, MD, Ph.D., mongoli ea ka sehloohong le Moprofesara. ea Gastroenterology ho Amsterdam University Medical Centers. "Mirikizumab e na le monyetla oa ho fokotsa ho ruruha haholo, ho thusa batho ho fumana tšoarelo le ho fokotsa ho potlaka ha mala, e leng sephetho se mabapi le mokuli se e-so ka se ithutoa pele tekong ea Mokhahlelo oa 3 bakeng sa lefu la ulcerative colitis."

Thuto ena ea lefats'e ea bakuli ba 1,162 e ne e kenyelletsa bakuli ba e-s'o ka ba leka phekolo ea biologic (biologic-naïve) le bakuli ba thata ho phekola bao pele ba neng ba nkile biologic e ileng ea hlōleha. Mokuli a le mong ho ba bane ba neng ba phekoloa ka mirikizumab (24.2%, n = 210/868) o fihletse pheletso ea mantlha ea tšoarelo ea kliniki libekeng tse 12, ha a bapisoa le a le mong ho ba supileng ho placebo (13.3%, n = 39/294, p = 0.00006), e bontšang ho imoloha ha matšoao a ntlafetseng le tharollo kapa haufi le tharollo ea ho ruruha. Hoo e ka bang karolo ea bobeli ho tse tharo ea bakuli ba nkang mirikizumab (63.5%, n = 551/868) ba fihletse karabelo ea bongaka, ha ba bapisoa le ba ka tlase ho halofo ea bakuli ba tšoaroang ka placebo (42.2%, n = 124/294, p<0.00001). Bakeng sa mokhoa, sheba karolo ea "About the LUCENT-1 Study" ka tlase.

Hoo e ka bang halofo ea bakuli ba nkang mirikizumab (45.5%, n = 395/868) ba fihletse phokotso ea matšoao libekeng tse 12, ha ba bapisoa le bakuli ba ka tlase ho karolo ea boraro ea bakuli ba nkang placebo (27.9%, n = 82/294, p <0.001). Hoo e ka bang libeke tse 'nè, bakuli ba fetang a le mong ho ba bahlano ba ileng ba nka mirikizumab (21.8%, n = 189/868) ba bile le ntlafatso e potlakileng matšoao a bona, ha ba bapisoa le hoo e ka bang mokuli a le mong ho ba robeli ba nkang placebo (12.9%, n = 38) /294, leq<0.001).

Hoo e ka bang libeke tse peli le ho feta libeke tse 12, bakuli ba neng ba phekoloa ka mirikizumab ba bile le phokotso e kholo ea lipalo-palo ka tekanyo ea 11-ntlha ea ho potlaka ha mala. Libekeng tsa 12, bakuli ba ne ba e-na le phokotso ea karolelano ea lintlha tsa 2.59 (2.32 ho 2.85), ha li bapisoa le ho fokotseha ha karolelano ea lintlha tsa 1.63 (1.18 ho 2.09) bakeng sa bakuli ba placebo (p <0.00001). Qetello ea ho potlaka ha mala a libeke tse 2 e ne e hlalositsoe esale pele empa e ne e sa laoloe ka bongata.

Boemo ba polokeho ka kakaretso bo ne bo ts'oana le lithutong tsa pele tsa mirikizumab ho UC 'me li tsamaellana le tsa li-anti-IL-23p19 tse ling libakeng tse ling tsa kalafo. Bakuli ba nkang mirikizumab, ha ba bapisoa le ba sebakeng sa placebo, ba tlalehile sekhahla se tlase sa liketsahalo tse mpe tse tebileng (mirikizumab: 2.8%, n = 27; placebo: 5.3%, n = 17) mme ba ne ba sa khone ho emisa thuto ka lebaka la liketsahalo tse mpe. mirikizumab: 1.6%, n=15; placebo: 7.2%, n=23).

Mabapi le mongoli

Avatar ea Linda Hohnholz

Linda Hohnholz

Mohlophisi e ka sehloohong bakeng sa eTurboNews e thehiloe ho eTN HQ.

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