Litaba tsa mohala

Thuto e Ncha ea ho Boloka Methapo ea Hao e Hloekileng

ngotsoeng ke mohlophisi

Ho tsosolosa mokhoa o ntseng o fokotseha ha re ntse re tsofala ho ka sireletsa khahlanong le atherosclerosis, sesosa se seholo sa lefu la pelo le stroke. Liphuputsong tse phatlalalitsoeng marang-rang kajeno ho Proceedings of the National Academy of Sciences (PNAS), bo-rasaense ba Albert Einstein College of Medicine ba eteletsoeng pele ke Ana Maria Cuervo, MD, Ph.D., ba atlehile ho fokotsa letlapa le fokotsang methapo ea mali ho litoeba tse neng li ka hlahisa tseo ho seng joalo. diso. Bafuputsi ba entse joalo ka ho matlafatsa chaperone-mediated autophagy (CMA), mokhoa oa ho boloka ntlo oa cellular oo Dr. Cuervo a ileng a o fumana ka 1993 mme a reha lebitso la 2000. 

“Re bontšitse phuputsong ena hore re hloka CMA ho itšireletsa khahlanong le lefu la atherosclerosis, le ntseng le mpefala ’me le hatela pele ha CMA e fokotseha—e leng ntho e etsahalang le ha batho ba tsofala,” ho boletse Dr. Cuervo, moprofesa oa baeloji ea tsoelo-pele le ea limolek’hule le bongaka. , Robert le Renée Belfer Molula-setulo oa Thuto ea Mafu a Neurodegenerative, le mookameli-'moho le Setsi sa Lipatlisiso tsa Botsofali ho Einstein. Empa ho bohlokoa ka ho tšoanang, re pakile hore ts'ebetso e ntseng e eketseha ea CMA e ka ba leano le sebetsang la ho thibela atherosclerosis le ho emisa tsoelo-pele ea eona.

CV e khahlisang ea CMA

CMA e boloka lisele li sebetsa ka mokhoa o tloaelehileng ka ho khetha ho nyenyefatsa liprotheine tse ngata tse nang le lisele. Ho CMA, liprotheine tse khethehileng tsa "chaperone" li tlama liprotheine tse ka har'a cytoplasm 'me li li tataisetsa ho li-enzyme tse tletseng li-cellular tse bitsoang li-lysosomes tse lokelang ho cheka le ho sebelisoa hape. Dr. Cuervo o hlalositse libapali tse ngata tsa limolek'hule tse amehang ho CMA mme a bontša hore CMA, ka ho senyeha ha eona ka nako ea liprotheine tsa bohlokoa, e laola mekhoa e mengata ea intracellular e kenyeletsang tsoekere le lipid metabolism, li-circadian rhythms le DNA tokiso. O ile a boela a fumana hore CMA e senyehileng e lumella liprotheine tse senyehileng hore li ipokellele maemong a chefo, e leng se tlatsetsang botsofaling le-ha motsoako o chefo o hlaha liseleng tsa methapo-ho mafu a neurodegenerative ho akarelletsa lefu la Parkinson, Alzheimer's le Huntington.

Liphihlello tsa Dr. Cuervo li ile tsa hlokomeloa ka 2019 ha a ne a khetheloa ho ea Sekolong sa Sechaba sa Saense (NAS). Ka 1996, NAS e ile ea qala ho memela litho tsa eona tse sa tsoa khethoa ho fana ka Sengoloa se ikhethileng sa Qalo ho PNAS se neng se tla totobatsa tlatsetso ea mahlale ea setho. Ka lebaka la tieho e amanang le seoa sa COVID-19, pampiri ea kajeno e mabapi le karolo ea ts'ireletso ea CMA khahlano le lefu la atherosclerosis ke pampiri ea PNAS ea Dr. Cuervo mme e eketsa mosebetsi oa hae mabapi le bohlokoa ba CMA.

WTM London ea 2022 e tla etsahala ho tloha ka la 7-9 Pulungoana 2022. Ngodisa hona joale!

Ho Loana Khahlanong le Plaque

Lefu la pelo (CVD) ke sesosa se ka sehloohong sa lefu lefatšeng, 'me ho feta karolo ea 80 lekholong ea lefu la CVD ka lebaka la lefu la pelo le stroke. CVD, le eona, hangata e amahanngoa le atherosclerosis: ho bokellana ha plaque (thepa e khomarelang e nang le mafura, k'holeseterole, k'halsiamo le lintho tse ling) ka har'a marako a methapo ea mali. Ho bokellana ha plaque ho thatafatsa le ho sesefatsa methapo ea mali, ho e thibela ho isa mali a nang le okosejene mesifang ea pelo (e lebisang tlhaselong ea pelo), boko (ho otla), le 'mele oohle.

Ho batlisisa karolo ea CMA ho atherosclerosis, Dr. Cuervo le basebetsi-'moho ba ile ba khothalletsa lefu la atherosclerosis ho litoeba ka ho ba fepa lijo tsa Bophirimela tse mafura bakeng sa libeke tsa 12 le ho shebella mosebetsi oa CMA ho li-aorta tse anngoeng ke plaque ea liphoofolo. Mosebetsi oa CMA qalong o ile oa eketseha ho arabela phephetso ea lijo; Leha ho le joalo, ka mor'a libeke tsa 12, ho bokellana ha plaque ho ne ho le bohlokoa, 'me ha ho na mosebetsi oa CMA o neng o ka fumanoa mefuteng e' meli ea lisele-macrophages le lisele tse boreleli tsa mesifa-tse tsejoang ka ho se sebetse hantle ha atherosclerosis, e leng se lebisang ho bokellaneng ha letlapa ka har'a methapo.

"CMA e ne e bonahala e le ea bohlokoa haholo ho sireletsa macrophages le lisele tse boreleli tsa mesifa-e li thusang hore li sebetse ka mokhoa o tloaelehileng ho sa tsotellehe lijo tsa pro-atherosclerotic-bonyane ka nakoana, ho fihlela mosebetsi oa bona oa CMA o fela," ho boletse Dr. Cuervo. O hlokometse hore ho fepa litoeba tse haellang ka ho felletseng tšebetsong ea CMA ho hlahisa bopaki bo matla le ho feta ba bohlokoa ba CMA: li-plaque tse kholo ka 40% ho feta tse laolang liphoofolo tse neng li le lijong tse mafura haholo.

Ea Litoeba le Hape Banna

Bafuputsi ba fumane bopaki ba hore ts'ebetso e fokolang ea CMA e amana le atherosclerosis le ho batho. Bakuli ba bang ba kileng ba otloa ke setorouku ba etsoa opereishene, e tsejoang ka hore ke carotid endarterectomy, e tlosang likarolo tse anngoeng ke plaque methapong ea bona ea carotid ho fokotsa kotsi ea ho otloa lekhetlo la bobeli. Dr. Cuervo le basebetsi-'moho le eena ba ile ba hlahloba mosebetsi oa CMA likarolong tsa methapo ea carotid ho tloha ho bakuli ba pele ba 62 ba ileng ba lateloa lilemo tse tharo ka mor'a ho buuoa.

"Bakuli bao ba nang le maemo a phahameng a CMA ka mor'a lichapo tsa bona tsa pele ha baa ka ba fumana ea bobeli, ha liropo tsa bobeli li etsahala hoo e batlang e le bakuli bohle ba nang le mosebetsi o fokolang oa CMA," ho boletse Dr. Cuervo. "Sena se fana ka maikutlo a hore boemo ba ts'ebetso ea CMA ea post-endarterectomy e ka thusa ho bolela esale pele kotsi ea ho otloa ke setorouku le ho tataisa kalafo, haholo-holo ho batho ba nang le CMA e tlase."

Ho hlahisa CMA, Ho Lokisa Atherosclerosis

Boithuto bona ke ba pele ho bonts'a hore ho hlahisa CMA e ka ba mokhoa o sebetsang oa ho thibela lefu la atherosclerosis ho ba matla kapa ho tsoela pele. Bafuputsi ba liphatsa tsa lefutso "CMA e laoloang" ka litoeba tse neng li feptjoa lijo tsa pro-atherosclerotic, tse mafura a mangata a Bophirimela 'me hamorao li li bapisa le litoeba tsa taolo tse fepa lijo tse tšoanang bakeng sa libeke tsa 12. Litoeba tse matlafalitsoeng ke CMA li ne li ntlafalitse haholo boemo ba lipid ea mali, ka maemo a fokotsehileng a k'holeseterole ha a bapisoa le litoeba tsa taolo. Likokoana-hloko tse entsoeng litoeba tse fetotsoeng ka liphatsa tsa lefutso li ne li le nyenyane haholo 'me li le bobebe ka ho teba ha li bapisoa le litoeba tse laolang litoeba. Ka lehlohonolo, batho ba ke ke ba hloka phetoho ea liphatsa tsa lefutso ho rua molemo phumaneng ena.

"'Na le basebetsi-'moho le 'na re thehile metsoako ea lithethefatsi e bontšitseng tšepiso ea ho eketsa ts'ebetso ea CMA ka mokhoa o sireletsehileng le ka katleho meleng e mengata ea litoeba le liseleng tse nkiloeng ke batho," ho boletse Dr. Cuervo. Einstein o kentse thepa ea mahlale ho theknoloji ena ea motheo.

Pampiri ea PNAS e bitsoa "Karolo ea Tšireletso ea chaperone-mediated autophagy khahlano le atherosclerosis." Bangoli ba bang ba Einstein e ne e le Julio Madrigal-Matute, Ph.D., Dario F. Riascos-Bernal, Antonio Diaz, MD, Ph.D., Inmaculada Tasset, Ph.D., Adrian Martin-Segura, Ph.D., Susmita Kaushik, Ph.D., Simoni Tiano, MD, Matthieu Bourdenx, Ph.D., Gregory J. Krause, MS, Nicholas Sibinga, MD, Fernando Macian, MD, Ph.D., le Rajat Singh, MD E 'ngoe ea pampiri sengoli se ngollanang le eena ke Judith C. Sluimer, Ph.D., oa Maastricht University Medical Center e Netherlands le Univesithi ea Edinburgh e United Kingdom.

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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