Lintlha tse Ncha mabapi le Mofuthu oa Antibody Autoimmune Hemolytic Anemia

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Rigel Pharmaceuticals, Inc. kajeno e phatlalalitse phatlalatso ea data ho American Journal of Hematology ho tloha ho label e bulehileng, multicenter, Phase 2 kliniki ea thuto ea fostamatinib ho batho ba baholo ba nang le mofuthu oa antibody autoimmune hemolytic anemia (wAIHA) ba neng ba hlōlehile bonyane phekolo e le 'ngoe pele. Lintlha tse hatisitsoeng li bontša hore fostamatinib, inhibitor ea spleen tyrosine kinase (SYK) ea molomo, e ile ea eketseha ka potlako le ka nako e telele maemo a hemoglobin (Hgb), e nang le likarabo tsa Hgb tse nang le moelelo oa bongaka tse hlokometsoeng hoo e batlang e le halofo ea bakuli, le boemo ba tšireletso le mamello bo lumellanang le bo teng. fostamatinib database ea polokeho ea bakuli ho pholletsa le mananeo a mangata a mafu a ithutoang. Phatlalatso, e nang le sehlooho se reng "Fostamatinib bakeng sa phekolo ea mofuthu oa antibody autoimmune hemolytic anemia: Phase 2, multicenter, open-label study", e fumaneha ho websaeteng ea koranta.

"Liphetho tse bonoang thutong ea rona ea Phase 2 mabapi le anemia e futhumetseng ea autoimmune hemolytic anemia e matlafatsa bokhoni ba fostamatinib ho thusa bakuli ba nang le lefu lena le sa tloaelehang, le tebileng la mali leo ho seng litlhare tse lebisitsoeng ho bona tse amoheloang hajoale," ho boletse Raul Rodriguez, mopresidente oa Rigel le molaoli ea ka sehloohong. ofisiri. "Haeba e amohetsoe, fostamatinib e na le monyetla oa ho ba kalafo ea pele ho mmaraka bakeng sa bakuli ba nang le wIHA ka 2023 mme e tla ba sesupo sa bobeli se amohetsoeng sa fostamatinib."

Boithuto ba Phase 2 bo ile ba lekola karabelo ho fostamatinib ho 150 mg BID (habeli ka letsatsi) ho bakuli ba baholo ba nang le wAIHA le hemolysis e sebetsang ka Hgb e ka tlase ho 10 g/dL ba neng ba hlolehile bonyane kalafo e le 'ngoe ea pele. Qetello e ka sehloohong e ne e le Hgb e kholo ho feta 10 g / dL ka keketseho ea ≥2 g / dL ho tloha qalong ka Beke ea 24 ntle le phekolo ea pholoso kapa tšelo ea lisele tse khubelu tsa mali. Phuputso e bontšitse hore 46% (11/24) ea bakuli ba fihletse ntlha ea mantlha ea ho qetela, le 1 ea arabelang morao ka beke ea 30 (kakaretso ea ba arabelang 12 [50%). Keketseho ea Hgb e bohareng e ile ea bonoa Bekeng ea 2 mme ea ts'oaroa ha nako e ntse e ea. Liketsahalo tse mpe tse atileng haholo (AEs) e ne e le letšollo (42%), mokhathala (42%), khatello ea mali (27%), ho tsekela (27%), le ho hlobaela (23%). Li-AE li ne li laoleha li bile li tsamaellana le database ea polokeho ea fostamatinib ea bakuli ba fetang 3,900 ho pholletsa le mafu a mangata (ramatiki ea ramatiki, B-cell lymphoma, COVID-19, le immune thrombocytopenia (ITP)). Ha ho matšoao a macha a tšireletso a fumanoeng.

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Avatar ea Linda Hohnholz

Linda Hohnholz

Mohlophisi e ka sehloohong bakeng sa eTurboNews e thehiloe ho eTN HQ.

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