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Ente e Ncha ea Tsoekere e Nchafatsoang bakeng sa Melioidosis

ngotsoeng ke mohlophisi

Tšokelo e tsoang ho Melioidosis ke ea sebele. Baktheria e bakang lefu lena le tšoaetsanoang la multisymptom ha e na lithibela-mafu, e leng se etsang hore tlhahlobo le kalafo e be thata le ho feta, 'me ho baka hore ho be le palo ea batho ba shoang e fihlang ho 50%. Moprofesa Charles Gauthier oa Institut national de la recherche scientifique (INRS) o qetile lilemo tse leshome tse fetileng a ithuta ka lefu le hlokomolohuoang la libaka tsa tropike. Kaha joale o se a fumane chelete e fetang $700,000 ka chelete ho tsoa ho Mekhatlo ea Lipatlisiso ea Bophelo bo Botle ea Canada (CIHR), joale o qala tlhahlobo ea pele bakeng sa ente ka tšebelisano le baprofesa Éric Déziel le Alain Lamarre.

Burkholderia pseudomallei e fumaneha seretseng le mobung, haholo linaheng tsa equatorial tse kang Australia, Thailand, India le Brazil. Ha moroallo kapa komello e hlaha, e ka silafatsa likaroloana tse ka holimo tse tsamaisoang ke moea. “Ka lebaka la ho phahama ha mocheso le kotsi e ntseng e eketseha ea likoluoa ​​tsa tlhaho, liphuputso li bolela esale pele keketseho ea tšoaetso le libaka tse kotsing. Re tlameha ho itokisetsa,” ho bolela Moprofesa Gauthier.

Nakong ea lilemo tse hlano tse tlang, sehlopha sa hae se tla etsa ente ea glycoconjugate. Ka hona, tsoekere e hlahang holim’a baktheria ena e tla amahanngoa le ntho e tsamaisang protheine e tsejoang ke lisele tsa T tsa ’mele—e leng “masole” a tsamaiso ea ’mele ea ho itšireletsa mafung a etsang hore ho be le masole a ’mele. Moprofesa Lamarre, ea sebetsanang le nts'etsopele ea ente, le Moprofesa Déziel, setsebi sa microbiology ea baktheria ea Burkholderia, ba tla etsa lithuto tsa ente ho litoeba le ho batlisisa mofuta oa likarabo tsa 'mele oa ho itšireletsa mafung.

Ketsiso ea tsoekere

Sehlopha sa bo-ramahlale se tla leka mefuta e mengata ea ente e nang le metsoako e fapaneng ea liketane tse tharo tsa tsoekere, kapa li-polysaccharides, tse hlahisoang ke baktheria. Tsoekere ea tšepisa hobane e se e tobisitsoe ke masole a 'mele. Ho e-na le ho li arola ka ho toba baktheria, Moprofesa Gauthier o sebelisa mehlala ea tsoekere ena e entsoeng mosebetsing oa hae oa pejana. Mokhoa ona o qoba kotsi ea ho sebetsana le pathogen.

WTM London ea 2022 e tla etsahala ho tloha ka la 7-9 Pulungoana 2022. Ngodisa hona joale!

"Re khonne ho etsa li-polysaccharides tse etsisang tsa baktheria, ntle le ho tsejoa ke li-antibodies. Ke mosebetsi oa bopula-maliboho,” o boletse joalo. Leha ho le joalo, mokhoa oa ho kopanya o tla hloka ho ntlafatsoa ho eketsa chai eohle ea tsoekere.

E le setho sa marang-rang a VALIDATE ea Univesithi ea Oxford bakeng sa nts'etsopele ea liente khahlanong le likokoana-hloko tse hlokomolohuoang, Moprofesa Gauthier a ka itšetleha ka thuso ea bo-rasaense ba tsoang lefats'eng lohle. E mong oa basebetsi-'moho le eena ke mofuputsi oa US Brad Borlee oa Colorado State University, ea mo fang mefuta e fokolang ea Burkholderia pseudomallei. Borlee e etsa tsoekere e tla sebelisoa e le taolo bakeng sa "ba etsisa" tsoekere lithutong tsa ente. Gauthier o boetse o sebetsa le Moprofesa Siobhán McClean oa Univesithi ea Dublin, mofuputsi oa Ireland ea fuputsang liprotheine tse hlahisoang ke baktheria. Liprotheine tseo le tsona li tobisitsoe ke sesole sa 'mele 'me li ka sebelisoa hammoho le tsoekere ho eketsa katleho ea ente.

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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