Ho Pholoha Kankere ea Ovary ho ka Boleloa esale pele

Bafuputsi ba Nagourney Cancer Institute le Metabolomycs, Inc. ba tla tlaleha kajeno Sebokeng sa Selemo le Selemo sa Mokhatlo oa Amerika oa Lipatlisiso tsa Kankere (AACR) New Orleans hore ba ile ba bolela esale pele ho pholoha ha bakuli ba mofetše oa mahe a bomme ka ho lekanya li-signature tsa metabolic sebakeng sa tumor microenvironment. Liphetho li ka ama bokamoso boo ho bona lingaka tsa oncologists li ka tsebang esale pele hore na mokuli o tla arabela joang kalafong e le ho ntlafatsa sephetho sa pholoho.

Ho ea ka bafuputsi, biology ea tumor ea motho e bonts'a tsoelopele ho tloha ho se tloaelehileng ho ea ho phetoho e mpe ho isa ho khanyetso ea lithethefatsi, e tsamaisoang ke ntlafatso ea metabolic lefatšeng ka bophara.

"Re kile ra bonts'a hore ho hanyetsa platinum ho mafu a basali ho boleloa esale pele ka liphetoho tsa metabolism tse lekantsoeng ka plasma ea bakuli nakong ea ho hlahlojoa," ho boletse Dr. Robert Nagourney, Mothehi le Mookameli oa Bongaka oa Nagourney Cancer Institute. "Hona joale re bonts'a hore "tumor microenvironment" e lekantsoeng mecheng ea litaba ea batho ba hlahisang hlahala 1o e fana ka leseli le ts'oanang mabapi le karabelo ea lithethefatsi bakeng sa kalafo e thehiloeng ho platinum.

Kankere ea mahe a bomme ke sesosa se ka sehloohong sa lefu la mofetše oa basali. Leha 80% ea linyeoe tsa mae a bomme li arabela kalafo e thehiloeng ho platinum, bongata ba linyeoe li khutla, 'me bakuli ba shoa nakong ea lilemo tse hlano. Ka thahasello e ntseng e hola ea metabolism ea motho e le karolo ea bohlokoa ea baeloji ea mofets'e, tlaleho ena e mabapi le mofetše oa mahe a bomme ke tlhahlobo ea morao-rao ho tse 'maloa tse entsoeng ke sehlopha mefuteng e mengata e tsoetseng pele ea mofets'e e tiisang karolo ea metabolomics ho khethollang ho pholoha.

Bafuputsi ba ile ba etsa quantitative tandem Mass Spectrometry (MS/MS) mecheng ea litaba ea setso sa lisele tsa mofetše oa mahe a batho ho hlahloba li-signature tsa metabolic tsa tumor microenvironment kamora matsatsi a 3 a setso ho RPMI 1640 e fetotsoeng.

Mass Spectrometry e entsoeng mecheng ea litaba ea lithane tsa bakuli ba 11 e bapisitse bakuli ba 8 ba fihletseng phokolo e felletseng ea pathologic (pCR) le bakuli ba bararo ba nang le lefu le setseng kaofela ba latela chemotherapy ea induction le Carboplatin le Paclitaxel. Litlhahlobo li ne li kenyelletsa li-amino acid, li-amine tsa biogenic, li-hexose, phosphatidylcholines, lyso-phosphatidylcholines le sphingomyelins.

Dr. Nagourney o itse: "Ka temohisiso e joalo, re mothating oa ho fumana mokhoa o nepahetseng oa phekolo bakeng sa ba nang le lihlahala tsa mahe a bomme."