Liteko tsa Batho Joale li Qala bakeng sa Ente e Thibelang Lefu la Parkinson

Har'a liente tsena tse 'nè, liphetho tse ntle ka ho fetisisa li ile tsa fumanoa ka PV-1950, eo ka nako e le' ngoe e lebisang li-epitopes tse tharo tsa B cell tsa molek'hule ena ea pathological, e bontšang phokotso e kholo ka ho fetisisa ea α-Synuclein le neurodegeneration bokong ba litoeba tsa hα-Syn D line.            

Ngaka Agadjanyan o itse, “Ho etsoa ha ente e sireletsehileng le e thibelang mafu e lebisitseng mefuta eohle ea pathological α-Synuclein ke sepheo sa IMM. Habohlokoa, ente ea rona e sebetsang ka ho fetesisa, PV-1950, e hlahisitse tlhahiso e matla ea li-antibody, e fokotsang pathological α-Synuclein le ho ntlafatsa khaello ea makoloi mofuteng oa toeba ea lefu e se e loketse ho lekoa litekong tsa thibelo ea kliniki ". O ile a tsoela pele, "PV-1950 e na le liphetolelo tse peli - e 'ngoe e thehiloe ho DNA le e' ngoe ka protheine e kopantsoeng hape. Ente e tlatselletsang e matlafatsang e nang le liente tse fapaneng tsa DNA le liprotheine ke mokhoa o mong hape o ts'episang oa ho fana ka karabelo e kholo ea sesole sa 'mele. ”

PD ke lefu la bobeli le atileng ka ho fetesisa la neurodegenerative la botsofali le amang ts'ebetso ea motlakase le ea kelello. Setsi se shebana le kalafo e thibelang mafu a amanang le neurodegenerative e thehiloeng ho ente e kang PD, DLB, le AD. Ente ea immunogenic e ka ba mokhoa o sebetsang ka ho fetisisa oa ho thibela / ho thibela ho bokellana ha protheine e chefo ea α-Synuclein ho tloha ho bokella le ho hasana ka bokong le ho emisa kapa ho liehisa lefu lena, ho boletse IMM.

“α-Synuclein ke protheine ea neuronal e hokahaneng ka liphatsa tsa lefutso le neuropathologically le mefuta e fapaneng ea α-synucleopathies, ho kenyeletsoa lefu la Parkinson (PD). Hang ha lefu lena le qala, ho batla ho sa khonehe ho e emisa, kahoo ho sebelisa ente ea MultiTEP e thehiloeng sethaleng e tsoang ho IMM Nuravax e batla ho emisa kapa ho liehisa lefu lena ho batho ba kotsing ea α-synucleopathies, "ho boletse Roman Kniazev.