Litaba tsa mohala

immunotherapy e ncha bakeng sa kalafo ea pheko ea peanut

ngotsoeng ke mohlophisi

Aravax, k'hamphani ea kliniki ea biotechnology e shebaneng le ho nts'etsapele kalafo ea pele bakeng sa allergy ea peanut e etselitsoeng ho bolokeha, e sebetsang le e bonolo, kajeno e phatlalatsa hore e fumane leseli le letala bakeng sa ts'ebeliso ea eona ea Investigational New Drug (IND) ho tsoa ho US Food and Tsamaiso ea Lithethefatsi (FDA).

PVX108 ke moloko o latelang, allergen-specific immunotherapy e sebelisang li-peptide tse emelang likaroloana tsa bohlokoa tsa liprotheine tsa peanut ho lebisa ka ho toba lisele tsa T tse tsamaisang ho kula ha peanut. E tsamaisoa hanngoe ka khoeli, kalafo e etselitsoe ho khothaletsa mamello ho protheine ea peanut ntle le mathata a polokeho a thibelang ts'ebeliso ea kalafo e ngolisitsoeng feela e sebelisang li-extracts tsa tlhaho ho tsoa ho matokomane. Ho ba teng ha lintho tse amanang le peanut allergens liqotsong tseo ho pepesetsa bakuli likotsi tse kholo tsa anaphylaxis (Chu et al. The Lancet 2019).

IND e tla lumella Aravax ho ntšetsa pele lenaneo la liteko tsa bongaka tsa Phase 2 ho la US le ho holisa ts'ebetso ea lona ea lefats'e.

"Re thabetse ho arolelana hore FDA e lumelletse Aravax ho qala thuto ea katleho ea Mokhahlelo oa 2 ho fumana tekanyo e nepahetseng ea PVX108 ho bana ba nang le bothata ba peanut United States. Sena ke sebaka sa kalafo se hlokomolohuoang haholo, 'me re lumela hore mokhoa oa rona o na le melemo e mengata ho feta liphekolo tse fumanehang ka mokhoa o nepahetseng oa ts'ebetso le ts'ireletso e seng e netefalitsoe litekong tsa bongaka tsa Mokhahlelo oa 1." ho boletse CEO ea Aravax, Ngaka Pascal Hickey.

Nakong e fetileng, teko ea Phase 1 e laoloang ka makhetlo a mabeli, e sa boneng habeli, e laoloang ke placebo ho batho ba baholo ba 66 ba peanut-allergic (AVX-001) ha ea ka ea bontša bopaki ba liketsahalo tse mpe tsa ho ameha ka meriana. Ho feta moo, lithuto tsa ex vivo tse fanang ka tekanyo ea tšireletso (basophil activation) ho bafani ba mali ba 185 ba peanut-allergic ba netefalitse ho haella ha basophil reactivity ho PVX108 ho fapana le peanut extract. Lintlha tsena li bonts'a hore PVX108 e na le ts'ireletso e ntle haholo bakeng sa kalafo ea bakuli ba allergy ea peanut, ho kenyeletsoa le ba nang le allergy e matla.

WTM London ea 2022 e tla etsahala ho tloha ka la 7-9 Pulungoana 2022. Ngodisa hona joale!

Patent ea pele ea Aravax e akaretsang sebopeho sa pele sa PVX108 e boetse e fanoe US, EU le libakeng tse ling. Malapa a tlatsetso ea litokelo tsa molao le ona a ntse a tsoela pele hantle libakeng tsena.

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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