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Tlhahisoleseding e Ncha mabapi le Hore na Crosstalk Pakeng tsa Lisele Tsa Pancreatic e Ka Tsamaisa Mofuta o sa tloaelehang oa Lefu la tsoekere

ngotsoeng ke mohlophisi

Li-enzyme tse silang lijo tse feto-fetohang li bokellana liseleng tsa beta tse haufi tse hlahisang insulin, e leng se bakang boemo bo futsitsoeng bo ka hlakisang mafu a mang a manyeme.

Ho manyeme, lisele tsa beta tse hlahisang insulin li kopantsoe le lisele tse ling tsa endocrine tse hlahisang lihomone 'me li pota-potiloe ke lisele tsa "pancreatic exocrine" tse hlahisang li-enzyme tsa tšilo ea lijo. Bafuputsi ba Joslin Diabetes Center joale ba bonts'itse hore na mofuta o mong oa lefu le sa tloaelehang le futsitsoeng le tsejoang ka hore ke lefu la tsoekere la mature on the young (MODY) le tsamaisoang ke li-enzyme tsa tšilo ea lijo tse hlahisoang ka liseleng tsa pancreatic exocrine, ebe li nkuoa ke lisele tsa beta tse hlahisang insulin.

Sephetho sena se ka thusa ho utloisisa mafu a mang a manyeme, ho kenyelletsa mofuta oa 1 kapa lefu la tsoekere la mofuta oa 2, moo ho kopana ho sa tloaelehang ha molek'hule lipakeng tsa lihlopha tsena tse peli tsa lisele ho ka bapalang karolo e mpe, ho boletse mofuputsi e moholo oa Joslin Rohit N. Kulkarni, MD, PhD, Hlooho ea Co-Section ea Karolo ea Joslin's Islet le Regenerative Biology le Moprofesa oa Bongaka Sekolong sa Bongaka sa Harvard.

Mefuta e mengata ea MODY e bakoa ke phetoho e le 'ngoe ea liphatsa tsa lefutso tse hlahisang liprotheine liseleng tsa beta. Empa ka mofuta o mong oa MODY o bitsoang MODY8, mofuta o fetotsoeng ka har'a lisele tse haufi tsa kantle ho naha o tsejoa ho qala ts'ebetso ena e senyang, ho boletse Kulkarni, sengoli se tsamaisanang le pampiri ea Nature Metabolism e hlahisang mosebetsi. Bo-rasaense ba laboratoring ea hae ba fumane hore ho MODY8, li-enzyme tsa tšilo ea lijo tse hlahisoang ke motsoako ona o fetotsoeng ka har'a lisele tsa beta 'me li senya bophelo ba tsona le ts'ebetso ea bona ea insulin.

"Le ha manyeme a endocrine le a exocrine a etsa likarolo tse peli tse fapaneng tse nang le mesebetsi e fapaneng, kamano ea bona e haufi ea anatomical e bopa qetello ea bona," ho boletse Sevim Kahraman, PhD, mofuputsi oa postdoctoral laboratoring ea Kulkarni le sengoli se etelletseng pele sa pampiri. "Boemo ba pathological bo hlahang karolong e 'ngoe bo senya e 'ngoe."

"Le hoja MODY8 e le lefu le sa tloaelehang haholo, le ka fana ka leseli mabapi le mekhoa e akaretsang e amehang ho nts'etsopele ea lefu la tsoekere," ho boletse Anders Molven, PhD, sengoli se kenyang letsoho le Moprofesa Univesithing ea Bergen, Norway. "Liphumano tsa rona li bonts'a hore na ts'ebetso ea lefu le qalang manyeme a kantle a ka qetellang a ama lisele tsa beta tse hlahisang insulin. Re nahana hore taba e joalo e mpe ea exocrine-endocrine e ka ba ea bohlokoa haholo bakeng sa ho utloisisa maemo a mang a lefu la tsoekere la mofuta oa 1. ”

Kulkarni o hlalositse hore mofuta oa CEL (carboxyl ester lipase) o fetotsoeng ho MODY8 le ona o nkuoa e le mofuta oa kotsi bakeng sa lefu la tsoekere la mofuta oa 1. Seo se hlahisa potso ea hore na linyeoe tse ling tsa lefu la tsoekere la mofuta oa 1 le tsona li na le liprotheine tse kopaneng tsa lisele tsa beta, o boletse joalo.

Boithuto bona bo qalile ka ho fetola mohala oa sele ea exocrine (acinar) ho hlahisa protheine ea CEL e fetotsoeng. Ha lisele tsa beta li ne li hlatsuoa ka tharollo ho tsoa liseleng tse fetotsoeng kapa tse tloaelehileng tsa exocrine, lisele tsa beta li ile tsa nka liprotheine tse fetotsoeng le tse tloaelehileng, tsa tlisa palo e phahameng ea liprotheine tse fetotsoeng. Liprotheine tse tloaelehileng li ile tsa senngoa ke mekhoa e tloaelehileng ea lisele tsa beta 'me tsa nyamela ka lihora tse' maloa, empa liprotheine tse fetotsoeng ha lia ka tsa etsa joalo, ho e-na le hoo li theha lihlopha tsa protheine.

Joale likarolo tsee tse kopaneng li ile tsa ama tšebetso le bophelo bo botle ba lisele tsa beta joang? Letotong la liteko, Kahraman le basebetsi-'moho le eena ba pakile hore lisele ha li hlahise insulin ha li batloa, li ile tsa ata butle, 'me li ne li le kotsing ea lefu.

O netefalitse liphuputso tsena ho tsoa mehala ea lisele ka liteko tsa lisele tse tsoang ho batho ba fanang ka liphallelo. Ka mor'a moo, o ile a kenya lisele tsa exocrine tsa motho (hape a hlahisa enzyme e fetotsoeng kapa e tloaelehileng ea tšilo ea lijo) hammoho le lisele tsa batho tsa beta ho etsa mohlala oa mouse o etselitsoeng ho amohela lisele tsa motho. "Esita le boemong boo, o ne a ka bontša hore protheine e fetotsoeng e boetse e nkuoa ke sele ea beta ha e bapisoa le protheine e tloaelehileng, 'me e etsa likarolo tse sa tsitsang," ho boletse Kulkarni.

Ho feta moo, ha bafuputsi ba hlahloba manyeme a tsoang ho batho ba nang le MODY8 ba shoeleng ka mabaka a mang, ba ile ba bona hore lisele tsa beta li na le protheine e fetotsoeng. O ile a re: "Ho bafani ba phetseng hantle, ha rea ​​​​fumana esita le protheine e tloaelehileng liseleng tsa beta."

"Pale ena ea MODY8 qalong e qalile ka tlhokomeliso ea bongaka ea bakuli ba nang le lefu la tsoekere le bona ba nang le mathata a tšilo ea lijo, e leng se entseng hore ho fumanoe mofuta o tšoanang oa liphatsa tsa lefutso," ho boletse Helge Raeder, MD, sengoli-'moho le Moprofesa Univesithing ea Bergen. "Phuputsong ea hajoale, re koala selikalikoe ka ho hokahanya liphetho tsena tsa bongaka ka mokhoa oa mochini. Ho fapana le seo re neng re se lebelletse, enzyme ea tšilo ea lijo eo hangata e neng e reretsoe maleng e ile ea khelosoa hore e kene sehleke-hlekeng sa manyeme se boemong bo kulang, e leng se ileng sa senya tlhahiso ea insulin.”

Kajeno, batho ba nang le MODY8 ba phekoloa ka insulin kapa meriana ea lefu la tsoekere ea molomo. Kulkarni le basebetsi-'moho le eena ba tla batla litsela tsa ho rala mekhoa ea phekolo e hlophisitsoeng haholoanyane le ea motho ka mong. "Mohlala, na re ka qhala metsoako ee ea liprotheine, kapa ra fokotsa pokello ea tsona ka har'a sele ea beta?" a rialo. "Re ka fumana lintlha ho seo re ithutileng sona mafung a mang a kang lefu la Alzheimer le Parkinson's a nang le mokhoa o tšoanang oa ho bokellana liseleng."

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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