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Litaba tsa mohala

Patlisiso e Ncha e Hlalosa Hore na Hobaneng COVID-19 e Baka Tahlehelo ea Monko

ngotsoeng ke mohlophisi

E phatlalalitsoe marang-rang ka la 2 Hlakubele koranteng ea Cell, phuputso e ncha e fumane hore ts'oaetso ea vaerase ea seoa, SARS-CoV-2, ka tsela e sa tobang e theola ketso ea li-olfactory receptors (OR), liprotheine tse holim'a lisele tsa methapo ea nko tse li bonang. limolek'hule tse amanang le menko. 

E tataisoa ke bafuputsi ba NYU Grossman School of Medicine le Columbia University, boithuto bo bocha bo ka boela ba fana ka leseli mabapi le litlamorao tsa COVID-19 mefuteng e meng ea lisele tsa boko, le litlamorao tse ling tsa methapo ea kutlo tsa COVID-19 joalo ka "moholi oa boko," hlooho, le khatello ea maikutlo.

Liteko li bontšitse hore ho ba teng ha kokoana-hloko haufi le lisele tsa methapo ea kutlo (li-neurone) liseleng tse nkhang hamonate li tlisitse inrushing ea lisele tsa 'mele tsa ho itšireletsa mafung, microglia le lisele tsa T, maikutlo ao le tšoaetso ea kokoana-hloko. Lisele tse joalo li ntša liprotheine tse bitsoang li-cytokine tse ileng tsa fetola tšebetso ea liphatsa tsa lefutso tsa lisele tsa methapo ea monko, le hoja kokoana-hloko e ke ke ea li tšoaetsa, ho bolela bangoli ba thuto-thuto. Moo tšebetso ea lisele tsa 'mele ea ho itšireletsa mafung e ne e tla fela ka potlako maemong a mang, bokong, ho ea ka khopolo ea sehlopha, pontšo ea 'mele ea ho itšireletsa mafung e tsoela pele ka tsela e fokotsang mosebetsi oa liphatsa tsa lefutso tse hlokahalang bakeng sa ho haha ​​​​li-receptors tsa monko.

Phetoho ho Architecture

Letšoao le leng le ikhethang la ts'oaetso ea COVID-19 ke tahlehelo ea monko ntle le nko e koetsoeng e bonoang le mafu a mang a kang sefuba se tloaelehileng, bafuputsi ba re. Maemong a mangata, tahlehelo ea monko e nka libeke tse 'maloa feela, empa ho feta liperesente tse 12 tsa bakuli ba COVID-19, ho se sebetse ha monko ho tsoela pele ka mokhoa oa ho fokotseha ho tsoelang pele ha bokhoni ba ho fofonela (hyposmia) kapa liphetoho tseleng eo motho a lemohang monko o tšoanang (parosmia).

Ho fumana leseli mabapi le tahlehelo ea monko e bakiloeng ke COVID-19, bangoli ba hajoale ba ile ba hlahloba litlamorao tsa limolek'hule tsa ts'oaetso ea SARS-CoV-2 ho li-hamster tsa khauta le liseleng tse nkhang hamonate tse nkiloeng litsing tse 23 tsa batho. Li-hamster li emela mohlala o motle, e leng liphoofolo tse anyesang tseo ka bobeli li itšetlehileng haholo ka kutlo ea monko ho feta batho, le tse kotsing ea ho tšoaetsoa ke lehare la nko.

Liphetho tsa phuputso li thehile holim'a ho sibolloa ka lilemo tse ngata hore ts'ebetso e fetolang liphatsa tsa lefutso e kenyelletsa likamano tse rarahaneng tsa 3-D, moo likarolo tsa DNA li fihlellehang habonolo mochining oa ho bala liphatsa tsa lefutso ho latela matšoao a bohlokoa, le moo liketane tse ling tsa DNA li kenang. ho pota-pota ho theha likamano tsa nako e telele tse nolofalletsang ho bala ka mokhoa o tsitsitseng oa liphatsa tsa lefutso. Liphatsa tsa lefutso tse ling li sebetsa "liphaposing" tsa chromatin - liprotheine tse nang le liphatsa tsa lefutso - tse bulehileng le tse sebetsang, ha tse ling li kopane li bile li koetsoe, e le karolo ea "mehaho ea nyutlelie."

Boithutong ba hajoale, liteko li netefalitse hore ts'oaetso ea SARS-CoV-2, le karabelo ea 'mele ea ho itšireletsa mafung ho eona, e fokotsa bokhoni ba liketane tsa DNA ho li-chromosome tse susumetsang sebopeho sa moaho oa monko o monate hore o bulehe le ho sebetsa, le ho pota-pota ho qala. polelo ea lefutso. Lithishung tsa hamster le tsa batho tse nkhang hamonate, sehlopha sa lipatlisiso se fumane phokotso e ntseng e tsoela pele le e atileng ea moaho oa li-receptor olfactory. Mosebetsi o mong o rometsoeng ke bangoli bana o fana ka maikutlo a hore li-neurone tse nkhang hamonate li hokeletsoe libakeng tse tebileng tsa boko, le hore karabelo e tsoelang pele ea lisele tsa 'mele ea ho itšireletsa mafung ka har'a nko e ka ama maikutlo, le bokhoni ba ho nahana ka mokhoa o hlakileng (temoho), e tsamaellanang le COVID e telele.

Liteko tsa li-hamster tse tlalehiloeng ha nako e ntse e ea li senotse hore phokotso ea li-receptor tsa neuron tse nkhang hamonate li ile tsa tsoela pele ka mor'a liphetoho tsa nakoana tse ka amang kutlo ea monko ka tlhaho. Bangoli ba re sena se fana ka maikutlo a hore COVID-19 e baka tšitiso e tšoarellang nako e telele taolong ea chromosomal ea polelo ea lefutso, e emelang mofuta oa "memori ea nyutlelie" e ka thibelang ho khutlisoa ha OR sengoloa le kamora hore SARS-CoV-2 e hlakoloe.

Mohato o latelang, sehlopha se ntse se sheba hore na ho phekola li-hamster tse nang le COVID e telele ka li-steroids ho ka thibela ts'ebetso e senyang ea 'mele ea ho itšireletsa mafung (ho ruruha) ho sireletsa meaho ea nyutlelie. 

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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