Patlisiso e Ncha ea Phekolo ea Kankere ea Pancreatic

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Loki Therapeutics kajeno e phatlalalitse lingoliloeng tsa lipatlisiso koranteng, "Science Translational Medicine", e bontšang bokhoni ba AWAKE-LM-TT ho phekola kankere ea pancreatic. AWAKE-LM-TT, e hlahisitsoeng ke Claudia Gravekamp, ​​Ph.D., Mothehi-'moho le Loki le Moprofesa ea Associated oa Microbiology & Immunology ho Albert Einstein School of Medicine, e tšehetsa ente ea bongoana bakeng sa tetanase ho hlahisa sesole sa 'mele se matla le hang hang. karabelo ho lihlahala tse tiileng le metastase tse hlahisang li-antigen tsa tetanase.

Buka e ngotsoeng ka letsoho e reng, "Listeria e Fana ka Tetanus Toxoid Protein ho Pancreatic Tumors 'me e Eketsa Kankere Cell Death ho Litoeba,"' me e ngotsoe ke Dr. Gravekamp, ​​Ph.D., e hlalosa lipatlisiso tse amanang le mokhoa o mocha oa ho phekola mofetše oa pancreatic moo Listeria monocytogenes e leng teng. e sebelisetsoang ho fana ka liprotheine tse ngata tsa immunogenic tetanus toxoid (TT) ka ho toba liseleng tsa hlahala. Phano ena, Listeria-TT, e ile ea bontšoa ho hlahisa karabelo ea 'mele ea ho itšireletsa mafung, ho kenya tšebetsong lisele tsa T tsa memori e khethehileng ea tetanus toxoid ho bolaea lisele tsa tumor tsa pancreatic ductal adenocarcinoma (PDAC) litoeba. Ha e kopantsoe le gemcitabine (Listeria-TT + GEM), bafuputsi ba hlokometse phokotso ea 80% ea moroalo oa hlahala ea PDAC le phokotso ea 87% ea metastase ka keketseho ea ho pholoha ka 40% ha e bapisoa le litoeba tse sa phekoloang, ho fana ka maikutlo a hore li-antigens tse hopotsang Listeria li ka ba teng. mokhoa o mong oa phekolo ea immunotherapy ea kankere ea neoantigen.

Mothehi le CEO oa Loki Chris Bradley o itse, "Phuputso ena e mpa e le ntlha ea bohlokoa ha ho tluoa tabeng ea ho khetholla le ho fumana mekhoa ea phekolo e sebetsang ea ho phekola kankere e thata. Ho thata ho tseba hore na mofets'e oa manyeme o sa le qalong, e leng se etsang hore ho fumana kalafo ho be thata le ho feta, kaha hangata o fumanoa a le maemong a holimo kapa a morao. Patlisiso ena e bonts'a bokhoni bo boholo ba Loki's AWAKE-LM-TT e le pheko e ncha ea mofetše oa pancreatic e fuoang bokhoni ba eona ba ho sebelisa ente ea bongoana bakeng sa tetanus toxoid ho hlahisa karabelo e matla le e potlakileng ea 'mele ea ho itšireletsa mafung ho lihlahala tse tiileng le metastase e hlahisang li-antigen tsa tetanase.

Dr. Gravekamp o hlalositse, “Ka lebaka la phuputso ena, re na le leano le lecha leo e ke keng ea e-ba feela mokhoa o atlehileng oa ho itšireletsa mafung ho alafang mofetše oa manyeme, empa le mefetše e meng. Lihlahala tsa Pancreatic li thata haholo ho alafa ka hore, tsamaisong ea 'mele ea ho itšireletsa mafung, lihlahala tsena ha li hlahe ka ho lekaneng 'lisele' ho hohela tlhokomelo ea sesole sa 'mele 'me hangata li ka hatella karabelo efe kapa efe ea 'mele ea ho itšireletsa mafung e etsahalang. Mokhoa oa rona o etsa hore lihlahala tsena tse 'batang' tse thibelang mafu li chese ka ho lekaneng hore sesole sa 'mele se khone ho hlasela le ho timetsa.”

Loki o itokisetsa ho kenya kopo ea Investigational New Drug (IND) ho US Food & Drug Administration bakeng sa lenaneo la pele la motho la kliniki le etsang lipatlisiso tsa AWAKE-LM-TT kalafo ea mofetše oa pancreatic. Ha a fumana tumello ea FDA bakeng sa IND, Loki o lebelletse ho qala teko ea bongaka ea Mokhahlelo oa 1 halofong ea bobeli ea 2022.

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Avatar ea Linda Hohnholz

Linda Hohnholz

Mohlophisi e ka sehloohong bakeng sa eTurboNews e thehiloe ho eTN HQ.

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