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Liphetho tse ka Sehloohong tse tsoang ho Phekolo ea Matšoao a ho Khutlisa ho ilela khoeli

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Kajeno Astellas Pharma Inc. e phatlalalitse liphetho tsa mantlha ho tsoa tekong ea bongaka ea Phase 3 SKYLIGHT 4™ e fuputsang polokeho ea nako e telele ea fezolinetant, motsoako oa lipatlisiso oa molomo, o se nang hormone o ithutoang bakeng sa kalafo ea matšoao a mahareng ho isa ho a matla a vasomotor a amanang le menopause (VMS) e tla ts'ehetsa litlatsetso tsa nako e tlang tsa taolo ea ho kenya. VMS, e khetholloang ke hot flashes (hape e bitsoa hot flushes) le/kapa ho fufuleloa bosiu, ke matšoao a tloaelehileng a ho khaotsa ho ilela khoeli.1,2      

SKYLIGHT 4 ke teko ea bongaka e laoloang ke placebo, e foufetseng habeli ea Phase 3 ho basali ba fetang 1,800 ba batlisisang polokeho ea nako e telele (libeke tse 52) ea fezolinetant ho basali ba batlang kalafo bakeng sa phomolo ea VMS e amanang le ho khaotsa ho ilela khoeli. Maikemisetso a mantlha a thuto e ne e le ho lekola phello ea fezolinetant ho bophelo bo botle ba endometrial le polokeho ea nako e telele le mamello ea fezolinetant. Qetello ea mantlha ea tlhahlobo ea bophelo bo botle ba endometrial e fihletsoe mme liketsahalo tse atileng haholo tsa kalafo tse hlahang (TEAE) e ne e le hlooho le COVID-19, tse tsamaellanang le placebo. Lintlha tse ka holimo li boetse li bontša boemo ba nako e telele ba tšireletso ea fezolinetant 'me e tla tsebisa litokomane tsa tsamaiso nakong e tlang. Liphetho tse qaqileng li tla romelloa hore li phatlalatsoe le hore li sekasekoe libokeng tse tlang tsa bongaka.

"Ho ipapisitsoe le tlhahlobo ea rona ea pele, re thabetse sephetho sa thuto ea SKYLIGHT 4, e bonts'ang ts'ireletso ea nako e telele ea fezolinetant," ho boletse Nancy Martin, MD, PharmD, Motlatsi oa Motlatsi, Global Medical Head, Medical Specialties, Astellas. . "Ka lintlha tsena tsa fezolinetant, re na le tšepo ea hore re tla ba le monyetla oa ho fana ka khetho ea pele ea kalafo, e seng ea li-hormone bakeng sa VMS e itekanetseng ho isa ho e matla e amanang le ho khaotsa ho ilela khoeli."

"Matšoao a Vasomotor a atisa ho tlalehoa e le matšoao a tšoenyang ka ho fetisisa a ho khaotsa ho ilela khoeli, leha ho le joalo ho bile le mekhoa e fokolang haholo sebakeng sena sa phekolo," ho boletse Genevieve Neal-Perry, MD, Ph.D., Molula-setulo, UNC School of Medicine Lefapha la Obstetrics le. Thuto ea mafu a basali. Ke thabisoa ke monyetla oa khetho e ncha ea phekolo e sa sebeliseng li-hormone bakeng sa basali ba nang le VMS e itekanetseng ho isa ho e matla e amanang le ho khaotsa ho ilela khoeli.

Liphuputso tsa SKYLIGHT 4, hammoho le liphetho tsa liteko tse peli tsa bohlokoa tsa Mokhahlelo oa 3, SKYLIGHT 1™ le SKYLIGHT 2™, li tla fana ka lintlha tsa motheo bakeng sa tlhahiso ea taolo US le Europe.

Fezolinetant ke mohanyetsi oa li-receptor tsa neurokinin-3 (NK3) oa lipatlisiso. Tšireletseho le katleho ea fezolinetant li ntse li etsoa lipatlisiso 'me ha li so thehoe. Haeba e amohetsoe ke ba boholong ba laolang, fezolinetant e ka ba khetho ea pele ea kalafo, e seng ea lihormone ho fokotsa khafetsa le ho teba ha VMS e amanang le ho khaotsa ho ilela khoeli.

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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