Tobetsa mona ho bonts'a lifolakha tsa HAO leqepheng lena mme u lefelle katleho feela

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Phuputso e ncha e bontša hore batho ba fetang limilione tse 1 ba tla shoa selemo se seng le se seng ka lebaka la mofetše oa sebete

ngotsoeng ke mohlophisi

Mokhatlo oa Lefatše oa Bophelo o rera hore ho qala ka 2030, batho ba fetang milione ba tla shoa selemo le selemo ka lebaka la mofetše oa sebete. Cold Spring Harbour Laboratory (CSHL) Moprofesa Adrian Krainer, eo e kileng ea e-ba postdoc Wai Kit Ma, le Dillon Voss, Univesithi ea Stony Brook MD-Ph.D. moithuti-ka-bolulo ka lab Krainer's, ba tlile ka mokhoa oa ho kena-kenana le tsela ea matla e lumellang mofets'e ona ho hola le ho ata. Haufinyane tjena ba phatlalalitse mosebetsi oa bona, oo e neng e le tšebelisano 'moho le Ionis Pharmaceuticals, koranteng ea Cancer Research.             

Bo-rasaense ba CSHL ba sebelisitse antisense oligonucleotides (ASOs), e leng metsoako ea maiketsetso ea liphatsa tsa lefutso tse tlamang ho RNA le ho fetola tsela eo lisele li etsang liprotheine. Limolek'hule tsena li fetola enzyme eo lisele tsa mofetše oa sebete li e sebelisang ho tloha mofuteng o mong oa pyruvate kinase protein (PKM2), eo hangata e hlahisoang ka liseleng tsa embryonic le mofets'e, ho ea ho mofuta o mong oa protheine ea pyruvate kinase (PKM1), e ntlafatsang boitšoaro ba ho thibela hlahala. Ho fetola tšebetso ea protheine ena ho ama tsela eo lisele tsa mofetše li sebelisang limatlafatsi ka eona, tse ka fokotsang kholo ea tsona. Joalokaha Krainer a hlalosa, "Se ikhethang ka mokhoa oo re o etsang ke hore re etsa lintho tse peli ka nako e le 'ngoe: re hana PKM2 mme re eketsa PKM1. Mme re nahana hore tsena ka bobeli li bohlokoa. ”

Li-ASO li tšepisa mofuta ona oa mofetše hobane ka mor'a ho li kenya ka tlas'a letlalo, 'mele o tla li romela ka ho toba sebeteng. Kankere ea sebete e ne e tla thibeloa hore e se ke ea hōla le ho nama le litho tse ling. Bafuputsi ba bone phokotso e kholo nts'etsopele ea lihlahala mefuteng e 'meli ea litoeba tseo ba ithutileng tsona. Boithuto bona bo thehile lipatlisisong tsa pejana ho lab ea Krainer moo ba fetotseng PKM2 ho PKM1 ka liseleng tse tsoetseng pele ho tsoa mofuteng o mabifi oa mofetše oa boko o bitsoang glioblastoma.

Leano lena le boetse le na le molemo o mong, kaha lisele tse phetseng hantle tsa sebete ha li etse RNA e tšoanang le eo li-ASO li neng li tla li lebisa liseleng tsa mofetše oa sebete. Seo se fokotsa monyetla oa ho ba le litlamorao tse sa lebelloang. Voss o re, "Ho khona ho fana ka kalafo ena ka kotloloho sebeteng, ntle le ho ama lisele tse tloaelehileng tsa sebete, ho ka fana ka khetho e sebetsang haholoanyane, e sireletsehileng ea ho alafa mofetše oa sebete nakong e tlang."

Krainer, ea sebetsang le antisense oligonucleotides mafung a mang a kenyeletsang cystic fibrosis le spinal muscular atrophy, o rerile ho tsoela pele ho sebelisa lisebelisoa tsena tsa phekolo ho batla litsela tsa ho phekola kankere ea sebete. Har'a lipotso tse ling, bafuputsi ba na le tšepo ea ho hlahloba hore na limolek'hule tsa RNA li ka thusa ho ba le metastase ea mofetše sebeteng ho tsoa lithong tse ling.

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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