Boteng ba lihlahala tsa pancreatic, lisele tse ling tsa 'mele tsa ho itšireletsa mafung li pshatla liprotheine tsa sebopeho ho limolek'hule tse tsosang kaho ea lisele tse teteaneng, tšitiso e tsebahalang ea kalafo, phuputso e ncha e fumana.
E etelletsoe pele ke bafuputsi ba NYU Grossman School of Medicine, boithuto bo mabapi le meshwork e teteaneng ea protheine e ts'ehetsang litho tsa 'mele le ho thusa ho aha lisele tse senyehileng bocha. Collagen protheine fibers, e leng karolo e kholo ea letlooeng, e lula e senyeha 'me e nkeloa sebaka ho boloka matla a tsitsitseng, hape e le karolo ea mokhoa oa ho folisa leqeba.
Liphuputso tse fetileng li bontšitse hore lisele tsa 'mele tsa ho itšireletsa mafung tse bitsoang macrophages li kenya letsoho tšebetsong e bitsoang desmoplasia, e bakoang ke phetoho e sa tloaelehang le ho kenngoa ho feteletseng ha collagen e thibelang kankere ea pancreatic. Sebakeng sena, li-macrophages li boetse li tsejoa ka ho kenya le ho senya collagen ka ketso ea protheine e bitsoang mannose receptor (MRC1).
Ho hatisa Inthaneteng ka April 4 ho Proceedings of the National Academies of Sciences, phuputso ea morao-rao e fumane hore collagen e senyehileng e ile ea eketsa palo ea arginine, amino acid e sebelisoang ke enzyme nitric oxide synthase (iNOS) ho hlahisa metsoako e bitsoang reactive nitrogen mefuta ea. (RNS). Sena le sona se ile sa etsa hore lisele tsa stellate tsa boahelani, tse tšehetsang li hahe meshes e thehiloeng ho collagen ho potoloha lihlahala, ho bolela bangoli ba thuto.
"Liphetho tsa rona li senoletse hore na lihlahala tsa pancreatic li etsa lenaneo la macrophages joang ho kenya letsoho ho aheng lithibelo tsa fibrotic," ho bolela sengoli sa pele sa thuto Madeleine LaRue, PhD. Nakong ea thuto, LaRue e ne e le seithuti se fumaneng mangolo laborateng ea sengoli se phahameng sa thuto Dafna Bar-Sagi, PhD, Moprofesa oa S. Farber oa Biochemistry le Molecular Pharmacology le Motlatsi oa Motlatsi oa Saense ho NYU Langone Health. "Morero ona oa limolek'hule o ka sebelisoa ho loants'a liphetoho tse amanang le mofets'e ka har'a lisele tse potolohileng lihlahala," ho eketsa LaRue.
Kankere ea Pancreatic ke sesosa sa boraro se bakang mafu a amanang le mofets'e United States, ka tekanyo ea lilemo tse hlano ea ho phela ea 10%. Kankere ea Pancreatic e ntse e le thata ho alafa ka karolo e kholo ka lebaka la marang-rang a pharalletseng a lisele tsa fibrotic ho potoloha lihlahala. Marang-rang ana ha a thibe feela ho fihlella ka mekhoa ea phekolo, empa hape e khothalletsa khōlo e mabifi.
Bakeng sa phuputso ea hona joale, liteko li bontšitse hore macrophages hōlileng ka lijana tsa limatlafatsi (litso), 'me ba fetoloa boemo ba bona ba kankere-mamello (M2), robehile hole collagen ho feta macrophages hore hlasela lisele tse kankere (M1). Ho feta moo, sehlopha se tiisitse ka letoto la liteko hore M2 macrophages e na le li-enzyme tse phahameng tse hlahisang RNS, tse kang iNOS.
Ho netefatsa liphuputso tsena ho litoeba tse phelang, sehlopha se ile sa kenya lisele tsa linaleli tse "fepiloeng pele" ka kholaje, kapa li bolokiloe sebakeng se sa feptjoang, mahlakoreng a liphoofolo tse ithutoang hammoho le lisele tsa mofetše oa pancreatic. Sehlopha se hlokometse keketseho ea liperesente tse 100 ho bongata ba likhoele tsa intra-tumoral collagen ka har'a lihlahala tse nkiloeng liseleng tsa mofetše tse kopantsoeng le lisele tsa linaleli tse alafiloeng pele ka collagen.
Habohlokoa, phuputso eo e bontšitse ka lekhetlo la pele hore macrophages haufi le lisele tsa kankere ea pancreatic, e seng feela ho nka le ho senya collagen e eketsehileng e le karolo ea ho senya liprotheine tse fepa khōlo e sa tloaelehang, empa hape li fetoloa ke ho senya, e le hore tsamaiso ea bona ea matla a ho sebetsa. (metabolism) e khutlisetsoa morao 'me e fana ka matšoao a ho bokellana ha fibrotic.
Bar-Sagi o re: "Sehlopha sa rona se ile sa sibolla mokhoa o kopanyang phetoho ea collagen le ho aha tikoloho e hananang le kalafo e potolohileng lihlahala tsa pancreatic," ho bolela Bar-Sagi. "Kaha tikoloho ena e teteaneng e le lebaka le ka sehloohong le etsang hore kankere ea pancreatic e bolaee hakana, kutloisiso e molemo ea likamano pakeng tsa ho senya protheine le ho haha litšitiso tse sireletsang ho tla hlokahala ho ntlafatsa phekolo ea lefu lena le senyang."
