Thuto e Ncha ea Pilot ka Lefu la Alzheimer

Seelos Therapeutics, Inc., k'hamphani ea biopharmaceutical ea boemo ba bongaka e tsepamisitseng maikutlo ho nts'etsopele ea liphekolo bakeng sa mathata a methapo ea methapo le mafu a sa tloaelehang, kajeno e phatlalalitse hore e amohetse lengolo la kananelo la Tsebiso ea Tlhahlobo ea Clinical (CTN) ho tsoa Lefapheng la Bophelo la Mmuso oa Australia. Therapeutic Goods Administration (TGA) bakeng sa phuputso ea sefofane ea SLS-005 (ente ea trehalose, 90.5 mg / mL bakeng sa infusion ea methapo) bakeng sa phekolo ea bakuli ba nang le lefu la Alzheimer. 

"Ts'ebetso ea Trehalose ho lefu la Alzheimer's e ikhethile kaha e thibela bobeli ba beta-amyloid pathology le tau aggregate mefuteng ea pele ea litoeba. Ts'ebetso ena e bonahala e le intraneuronal, e etsahalang ka har'a sele, e fapaneng le litlhare tse shebaneng le antibody. Ka bobeli liprotheine tsa amyloid precursor le tau oligomers li cytoplasmic ka har'a sele 'me li ka sebelisoa ke Trehalose ka ho kenya tsamaiso ea autophagy le proteasomal. Autophagy e kenyelelitsoe ho senyeha ha liprotheine tse ling tse sa phutholohang hape, "ho boletse Raj Mehra Ph.D., Molula-setulo le CEO oa Seelos. "Re lebelletse ho fumana bopaki le lintlha tsa bohlokoa mabapi le ho nepahala ha SLS-005 kalafong ea maemo ana a methapo, a sithabetsang haholo 'meleng, maikutlong le licheleteng ho bakuli le malapa a bona."            

Ntle le moo, Seelos o ile a fumana tumello ea ho etsa thuto ea baskete e bulehileng e bulehileng (ACTRN: 12621001755820) Australia ho lekola katleho ea SLS-005 mabapi le tsoelo-pele ea mafu le ho teba, hammoho le polokeho le mamello ea eona, ho barupeluoa ba nang le mafu a khethiloeng a neurodegenerative. ho akarelletsa le lefu la Huntington.

Setsi sa taolo ea Australia bakeng sa liteko tsa bongaka, TGA, le Khothaletso ea Lekhetho la 'Muso oa Australia oa Patlisiso le Nts'etsopele li fana ka monyetla o motle bakeng sa lik'hamphani tse nyane tsa US tsa biotech ho qala liteko tsa bongaka Australia ka boiteko ba ho potlakisa ho qala lithuto le ho sebelisa litleleniki tse matla tsa naha. bokgoni ba teko.