Thuto e Ncha ka Phello e Khahlanong le Lets'ollo ea Cashew Stem Bark Extract

Anacardium occidentale (Ao), sefate se tloaelehileng sa cashew, ke semela seo e leng khale se tsejoa mekhoeng ea meriana ea setso bakeng sa matla a sona a phekolo. Ka mohlala, ho tsebahala hore likarolo tse sa tšoaneng tsa sefate sena sa tropike, makhasi, makhapetla, thollo ea peō le marenene li na le phello e thibelang letšollo. Leha ho le joalo, mekhoa e nepahetseng ea ts'ebetso e ntse e le sephiri.            

Dr. Kayode E. Adewole oa Univesithi ea Medical Sciences, Nigeria, le basebetsi-'moho le eena ba ile ba leka ho senya mekhoa ka ho batlisisa mosebetsi o khahlanong le letšollo oa lekhapetla la stem la lifate tsa cashew. Maikutlo a bona a ts'episang a sa tsoa hatisoa ho Journal of Pharmaceutical Analysis.

E bakoa ke lintlha tse fapaneng tse kang ho se mamelle lijo, tšoaetso ea likokoana-hloko, lithethefatsi le mathata a mala, letšollo ke bothata bo boholo ba bophelo bo botle ba sechaba, 'me bo baka lefu le leholo la bana. Hangata, lefu lena le bonahala ka ho eketseha ha motility ea mala. Ho hlahloba mokhoa o khahlanong le lets'ollo oa makhapetla a cashew stem, bafuputsi ba tsepamisitse maikutlo litseleng tsa cellular le libapali tsa bohlokoa tsa limolek'hule tse amehang motility e sa tloaelehang ea mala mme ba etsa letoto la liteko tse thehiloeng ho lab.

Dr. Adewole oa hlalosa, "Letšollo le bakoa ke ho eketseha ha mesifa e boreleli ea mala, eo ka tloaelo e laoloang ke litsela tse tharo tsa neurophysiological, dopaminergic, cholinergic, le serotonergic. Ka hona, mokhoa oa rona oa liteko e ne e le oa ho susumetsa ka mokhoa oa maiketsetso ho sisinyeha ha gastric ka tsela e 'ngoe le e' ngoe ea litsela tsena ebe re bona hore na ke efe ho tsena e neng e thibetsoe ke lekhapetla la lekhapetla la cashew. Liteko tsa rona li ile tsa aroloa likarolo tse peli, in vivo, tse entsoeng ka litoeba tse phelang, le in vitro, tse entsoeng liseleng tsa mala.

Sehlopha se ile sa fana ka meriana e bakang motility ea mala, e leng metoclopramide (mohanyetsi oa dopamine receptor), carbachol (acetylcholine receptor agonist), le serotonin (e susumetsang li-receptor tsa serotonergic), ho arola lihlopha tsa litoeba. Lihlopha tse ling tse tharo li ile tsa fumana meriana e tšoanang empa li ile tsa phekoloa ka makhapetla a cashew stem.

Ba fumane hore karoloana e lokisitsoeng ea ethyl acetate ea moqomo (e ngotsoeng AoEF) e sitisitse haholo tsela ea cholinergic ea ho tsoa ka mpeng le ka mpeng empa e se na phello litseleng tse ling tse peli, e fana ka temohisiso e betere mabapi le ts'ebetso ea qotsulo.

E le karolo ea liteko tsa in vitro, bafuputsi ba ile ba qhelela marapo maleng a likolobe tsa Guinea 'me ba fumana hore maemong a holimo, AoEF e khatholla likhoele tsena ka nepo le ka mokhoa o tsoileng matsoho. Sena se ile sa bonoa esita le maqeba a neng a phekoloa pele ka AoEF ebe a phekoloa ka limolek'hule tsa prokinetic tse kang histamine, serotonin, le acetylcholine.

Ho feta moo, ka ho sebelisa spectroscopy ea khase ea chromatography-mass spectroscopy, sehlopha se ile sa tseba likarolo tse 24 tse teng ho AoEF. Liphuputso tse thehiloeng ho Bioinformatics li senoletse hore har'a metsoako ena, octadecanoic acid 2- (2-hydroxylethoxy) ethyl ester e ne e e-na le kamano e phahameng ka ho fetisisa e tlamang ho muscarinic acetylcholine receptor M3 (CHRM3). Sena se ile sa lumella sehlopha ho kopanya bopaki bo tsoang litekong tsohle tse fapaneng le ho fihla mokhoeng o ka bang teng oa ho nka khato.

Ho kopanya matla a tsebo ea setso le saense ea morao-rao, Dr. Adewole le sehlopha sa hae ba tšepa hore ho sibolloa ha bona ho tla khothalletsa ho etsoa ha litlhare tse ncha tse theko e tlaase bakeng sa ho phekola le ho laola letšollo.