Nchafatso e Ncha ea Phekolo e Sebetsang Khahlanong le Lisele Tsa Kankere Tse Hlaha

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Hoth Therapeutics, Inc. kajeno e phatlalalitse lintlafatso tsa ntlafatso bakeng sa buka ea eona ea kalafo ea mofetše, HT-KIT. Mokhoa o mocha oa Hoth, o sebelisang oligonucleotide ea antisense e tsitsitseng lik'hemik'hale ho shebisa proto-oncogene KIT ka ho fetolela lingoliloeng tsa KIT mRNA, e na le monyetla oa ho ba kalafo e lebisitsoeng ho KIT e le 'ngoe, kapa e kopane le mahlahana a shebileng pontšo ea KIT, kalafong ea Mafu a amanang le KIT.

Ka tumellano e tšehelitsoeng ea lipatlisiso tsa mahlale le Univesithi ea Naha ea North Carolina, sehlopha se sebelisitse mokhoa oa ho fetola liforeimi tsa HT-KIT mRNA liseleng tsa mast cell leukemia in vitro mme sa fumana hore polelo ea protheine ea KIT, lipontšo le ts'ebetso li fokotsehile. Kalafo e nang le HT-KIT e thibetse kholo ea lisele tsa mofetše le ho baka lefu la lisele ka lihora tse 72. Moetsong oa motho oa mast cell leukemia mouse, kholo ea hlahala le ho kenella ha litho tse ling li ile tsa fokotsoa mme lefu la lisele tsa hlahala le ile la eketseha ha HT-KIT e etsa hore ho be le c-KIT mRNA.

Hoth e kentse likopo tse 'maloa tsa patent ho sireletsa IP ena lefatšeng ka bophara. 

"Ka sethethefatsi sa rona sa HT-KIT, re hlakola lets'oao la mofets'e le amehang mafung a mangata a mabifi, joalo ka systemic mastocytosis, mast cell leukemia, lihlahala tsa mala le acute myeloid leukemia. Mokhoa oa rona o qoba maraba a amanang le liphetoho tsa KIT ka ho shebana le mRNA. Lekhalo la rona le latelang la lithuto tsa preclinical le ntse le tsoela pele, 'me re thabetse ho sebelisa liphetho bakeng sa kopano ea rona e reriloeng ea Pre-IND le FDA hamorao selemong sena," ho boletse Robb Knie, Ofisiri e Phahameng ea Hoth.

HT-KIT, setsi se secha sa limolek'hule, se khethiloe e le Sethethefatsi sa Likhutsana bakeng sa phekolo ea mastocytosis pejana ho 2022. HT-KIT Hoth e atlehile ho phethahatsa bokhoni ba ho etsa tlhahiso ea lithethefatsi tsa HT-KIT ka tšebelisano le WuXi STA.

FDA Orphan Drug Designation e fuoa liphekolo tsa lipatlisiso tse sebetsanang le mafu a sa tloaelehang kapa maemo a amang batho ba ka tlase ho 200,000 United States. Boemo ba lithethefatsi tsa likhutsana bo fana ka melemo ho baetsi ba lithethefatsi, ho kenyeletsoa thuso ts'ebetsong ea nts'etsopele ea lithethefatsi, likoloto tsa lekhetho bakeng sa litšenyehelo tsa bongaka, ho lokolloa litefellong tse itseng tsa FDA le lilemo tse supileng tsa ho ikhetholla ka mor'a tumello.

Mabapi le mongoli

Avatar ea Linda Hohnholz

Linda Hohnholz

Mohlophisi e ka sehloohong bakeng sa eTurboNews e thehiloe ho eTN HQ.

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