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Kalafo e Ncha ea Oral Microdose ea Autism

ngotsoeng ke mohlophisi

Nova Mentis Life Science Corp. e phatlalalitse hore e atlehile ho phethela thuto ea preclinical ea microdose ea psilocybin, laboratoring ea Dr. Viviana Trezza, Univesithi ea Rome Tre, Roma, Italy. Liphetho li fetisitse litebello tsohle ka liphuputso tsa hore tekanyo e tlase haholo ea psilocybin e nang le thepa ea Khampani e fetotse haholo bofokoli ba boitšoaro le kelello, joalo ka mohopolo oa temoho, ka mofuta oa lefutso oa X syndrome (FXS).    

“Sehlopha sa mahlale se etelletsoeng pele ke Dr. Hausman, hammoho le Dr. Viviana Trezza oa Univesithi ea Roma Tre, ba ntse ba tsoela pele ho fana ka liphetho tse tšepisang tsa pele ho kalafo. Lintlha tsa morao-rao tsa microdose tsa molomo ha li tiise feela empa li feta liphetho tsa rona tsa pele tse entsoeng ka ente," ho boletse Will Rascan, CEO oa NOVA. "Lintlha tse hlakileng tse nepahetseng li bohlokoa ha re ntse re itokisetsa ho kenya kopo ea rona ea teko ea bongaka ho Health Canada bakeng sa phuputso ea Phase 2A e hlahlobang psilocybin microdose therapy bakeng sa lefu le fokolang la X."

Autism spectrum disorder (ASD) ke boloetse bo rarahaneng ba neurodevelopmental boo ho bona ho se nang phekolo. Fragile X syndrome (FXS) ke mofuta o atileng haholo oa bokooa ba kelello bo futsitsoeng le sesosa sa khafetsa sa monogenic sa ASD (1). Sepheo sa thuto ea hajoale e ne e le ho lekola litekanyetso tse fapaneng tsa molomo tsa psilocybin ea k'hamphani ka mokhoa oa likhoto oa FXS. Potso e kholo e lokelang ho arajoa thutong ena ea pele ho kliniki e ne e le hore na phekolo ea microdose e ka ba khetho ea phekolo ho ASD, ha e bapisoa le tekanyo e le 'ngoe ea phekolo ea macrodose e amanang le hallucinogenic le litla-morao tse ling.

Ho sebetsa ha Psilocybin ho ile ha lekoa ho FXS, ho Fmr1 knock-out (Fmr1 KO) rat (Fmr1-Δexon 8) - mofuta o thehiloeng oa lefutso oa FXS (1). Taolo ea mefuta e hlaha le liphoofolo tsa Fmr1 KO li ile tsa phekoloa ka 0.1 mg/kg le 0.3 mg/kg oral psilocybin letsatsi le leng le le leng bakeng sa liphekolo tsa 6, ka nako ea libeke tse 2, le ka letsatsi la 18 li ile tsa etsoa tlhahlobo ea ho lemoha lintho. Re bile le liphetho tse ntle! Ka bobeli 0.1 le 0.3 mg/kg li ne li atlehile ho khutlisa bokooa ba kelello bo bontšitsoeng ke liphoofolo tsa Fmr1 KO. Ho feta moo, 0.1 mg / kg e ile ea sebetsa ka ho fetisisa, 'me ha e na litla-morao tse bonahalang. Tekanyetso ea 0.1 mg/kg ho rat e fetolela tekanyo e ka bang 1.5 mg ea molomo ho motho oa 70 kg.

“Ke thabile haholo hore ebe ke khona ho tlalehela basebeletsi ba tsa bongaka hore qetellong re ka ’na ra bula monyetla oa phekolo ea ASD, tlhoko ea bongaka e sa fihlellehang, e nang le phello e bohloko ho mokuli, lelapa le sechaba,” ho boletse Marvin S. Hausman MD, Molula-setulo oa Boto ea Keletso ea Saense ea NOVA. "Moetso oa likhoto oo re o sebelisitseng o etsisa likarolo tsa bohlokoa tse kang autistic ho batho, 'me liphetho tsa thuto li tšehetsa ka matla karolo ea bohlokoa ea phekolo ea microdose.

FXS. Ho feta moo, karabelo ena e ntle ho rat ea letsatsi le leng le le leng ka molomo oa 0.1 mg/kg psilocybin, e lekanang le tekanyo ea 1.5 mg ho motho oa 70 kg, e ka ba phekolo ea khetho ea ho fetola liphetoho tsa boitšoaro le bofokoli ba kelello, 'me mohlomong ho ba le karabelo ea nako e telele ea methapo ea kutlo bokong ntle le tlhoko ea litekanyetso tse kholo tsa lithethefatsi tsa kelello tse nang le litlamorao tse mpe tse amanang le hallucinogenic."

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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