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Lefu la COVID-19: Thuto e Ncha e Bontša Phokotso ea 70%.

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RedHill Biopharma Ltd., k'hamphani e ikhethang ea biopharmaceutical, kajeno e phatlalalitse liphetho ho tsoa ho litlhahlobo tse peli tse sa tsoa phethoa tse boletsoeng esale pele ho tsoa thutong ea Oral Opaganib (ABC294640) Phase 2/3 sepetleleng se matla sa COVID-19. Tlhahlobo ea pele e bonts'itse hore opaganib e fokolitse lefu haholo ha e fuoa bakuli ba fumaneng remdesivir le corticosteroids, e leng eona e fumanehang ka ho fetesisa ea tlhokomelo ea maemo (SoC) bakeng sa bakuli ba sepetlele. Tlhahlobo ea bobeli e ile ea boela ea bontša hore opaganib e ile ea fana ka molemo o moholo ka nako ea ho hlaphoheloa, e hlalosoang e le ho finyella lintlha tsa 1 kapa ka tlase ho WHO Ordinal Scale ka Letsatsi la 14. Khampani e ntse e tsoela pele lipuisano tsa taolo linaheng tse ngata, ka tumello ea tšohanyetso le ea ho rekisa. likopo tse ntseng li rereloa linaha tse itseng halofong ea pele ea 2022.    

Tlhahlobo e boletsoeng ea lefu, e etselitsoeng bakuli bohle ba phuputso ea Mokhahlelo oa 2/3 ba neng ba amohela remdesivir le corticosteroids qalong, e bonts'itse molemo o moholo oa lefu la 70.2% ho bakuli ba phekoloang opaganib, ka sekhahla sa lefu sa 6.98% (n = 3 / 43) bakeng sa letsoho la opaganib + SoC khahlano le 23.4% (n=11/47) bakeng sa placebo + SoC ka Letsatsi la 42 (p-value=0.034).

Tlhahlobo ea bobeli e boletsoeng esale pele e bonts'itse opaganib e fane ka phaello e kholo ea 34% ka nako ea ho hlaphoheloa, e hlalosoang e le ho fumana lintlha tsa 1 kapa ka tlase ho WHO Ordinal Scale ka Letsatsi la 14, le 37.4% ea bakuli ba phekoloang opaganib (n = 86/230) ho fihlela ketsahalo ena khahlanong le 27.9% ea bakuli (n = 65/233) ba tšoaroang ka placebo + SoC (p-value = 0.013, Hazard Ratio 1.49).

Khatelo-pele ea taolo e ntse e tsoela pele ho etsoa, ​​​​ka tlhahiso ea data ea opaganib e qalileng karolong ea bone ea 2021 US, Europe, UK le linaheng tse ling. Lipuisano li ntse li tsoela pele 'me tataiso ea pele mabapi le thuto e netefatsang le tsela e ka bang teng ea tumello e amohetsoe ho tsoa ho EU's EMA, US FDA, MHRA ea UK le tse ling. Ho ipapisitsoe le maikutlo a taolo a tsoang libakeng tse ling le likeletso tsa kantle tse amohetsoeng, Khampani e ntse e rera likopo tse ka bang teng tsa tumello le tumello ea ho bapatsa linaheng tse ling tse joalo halofong ea pele ea 2022.

Opaganib ea Oral e ile ea ithutoa thutong ea lefats'e ea Phase 2/3 ho bakuli ba sepetlele ba nang le pneumonia e matla ea COVID-19 (NCT04467840). Tlhahlobong e boletsoeng ea bakuli bohle ba thuto ea Phase 2/3 ba nang le PCR e ntle nakong ea tlhahlobo ea opaganib ba ntlafalitse nako e bohareng ea tumello ea vaerase ea RNA bonyane matsatsi a 4, ho fihlela tumello ea vaerase ea RNA nakong ea matsatsi a 10, athe sebaka se bohareng sa tumello e ne e le. ha e fihlelle pheletsong ea matsatsi a 14 kalafo ka letsoho la placebo (Hazard Ratio 1.34; nominal p-value=0.043, N=437/463). Ho feta moo, liphetho tsa tlhahlobo ea post-hoc ea data ho tsoa ho barupeluoa ba 251 ba hlokang Karolo ea Oksijene e bululetsoeng (FiO2) ho fihla le ho kenyelletsa 60% qalong (54% ea barupeluoa thutong) e bontšitse hore kalafo ka opaganib ea molomo e hlahisitse 62. % phokotso ea palo ea batho ba shoang hammoho le liphetho tse ntlafalitsoeng ka nako ea moea oa phapusi, nako e bohareng ea ho tsoa sepetlele, le monyetla oa ho kenella le moea o kenang sehlopheng sena se seholo sa bakuli ba sepetlele, ba seng ba le matla ka ho fetesisa ba COVID-19.

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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