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Teko e Ncha ea Clinical for Relapsed Acute Lymphoblastic Leukemia

ngotsoeng ke mohlophisi

JW Therapeutics e phatlalalitse tumello ea Investigational New Drug (IND) ho tsoa ho National Medical Products Administration (NMPA) ea Chaena bakeng sa thuto ea anti-CD19 autologous chimeric antigen receptor T (CAR-T) cell immunotherapy sehlahisoa Carteyva® (relmacabtagene autoleucel ente) ho alafa bakuli ba bana le ba bacha ba baholo ba nang le ho khutlela morao kapa ho hanyetsa B-cell acute lymphoblastic leukemia (r/r B-ALL).

B-cell acute lymphoblastic leukemia (B-ALL) ke lefu le atileng haholo ho bana[1]. Ho hanyetsa meriana ea chemotherapeutic ho bakang ho khutlela mokhoeng le tsoelo-pele, 'me ho phela ka mor'a ho khutlela mokhoeng hoa fokola ho bakuli ba nang le B-ALL. Kalafo ea "Salvage chemotherapy" e ka ba khetho, empa ha ea lekana ho alafa lefu le khutlelang morao kapa le mabifi. Ho phela ha nako e telele ho ne ho lekanyelitsoe ka lebaka la karabelo e fokolang, sekhahla se tlase sa tšoarelo, le sekhahla se phahameng sa ho khutlela mokhoeng ka mor'a chemotherapy ea pholoso. Hajoale, ha ho na kalafo e tloaelehileng e sebetsang bakeng sa r/r B-ALL. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) e hlahile e le leano le ts'episang, leha ho le joalo, sekhahla sa ho phela ha nako e telele se ntse se ke ke sa fihlela khotsofalo[2]. Boloetse bo khutlela morao ka mor'a liphekolo e ntse e le phephetso e kholo, 'me mekhoa e mecha ea phekolo e ntse e hlokahala ka potlako ho lelefatsa bophelo ba nako e telele bakeng sa bakuli ba nang le r/r B-ALL.

Boithuto bona (JWCAR029-006) mohato oa I, lengolo le bulehileng, letsoho le le leng, thuto ea ho nyolla lethal dose naheng ea China, e ikemiselitseng ho lekola polokeho, katleho, le profil ea pharmacokinetics ea Carteyva® ho bakuli ba bana le ba bacha ba baholo ba nang le r/r. B-ALL, le ho tseba hore na tekanyo ea mohato oa II e khothalletsoang (RP2D).

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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