Teko ea Gene Therapy bakeng sa Diabetic Neuropathy E 'ngoe ea Lingoloa tse Jarolloang Haholo

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Avatar ea Linda Hohnholz
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Helixmith o phatlalalitse kajeno hore khatiso ea bona, "Gene therapy for diabetic neuropathy: A randomised, placebo-controlled phase III ea VM202, plasmid DNA encoding human hepatocyte growth factor," e ne e le e 'ngoe ea lihlooho tse 10 tse jarollotsoeng ka ho fetisisa ho Clinical and Phetolelo ea Saense (CTS) ka 2021. CTS ke sengoliloeng sa molao sa American Society for Clinical Pharmacology & Therapeutics (ASCPT) mme e totobatsa liphuputso tsa mantlha tse thusang ho koala litšibollo tsa laboratori ka tlhahlobo le kalafo ea mafu a batho. Dr. John Kessler, Moprofesa oa Neurology Northwestern e ne e le mongoli ea ka sehloohong thutong ena. Ena e ne e le mohato oa pele oa phekolo ea lefutso mohato oa 3 o kileng oa etsoa bakeng sa bohloko. Ho ea ka Alethea Gerding, Managing Editor, ASCPT, "Sengoloa se kopitsoe ka makhetlo a fetang 3,000, ho bolelang hore se fihlile ho babali ba bangata lefatšeng ka bophara. Sepheo se seholo sa CTS ke ho ba lebone la saense ea phetolelo, ’me lihlooho tse kang tsa hao li bontša ka ho hlaka bohlokoa ba saense ea ho fetolela.”

Ka pampiri, VM202 (donaperminogene seltoplasmid), DNA ea plasmid e kenyelletsang liphatsa tsa lefutso tsa HGF (hepatocyte growth factor) ea motho, e entsoeng ke Helixmith Co. Ltd, bangoli ba tlaleha hore VMDN-003b, liente tsa intramuscular tsa VM202 li fane ka ho fokotsa bohloko ho feta 8. likhoeli ka mor'a potoloho ea ho qetela ea phekolo le hore polokeho le mamello li ne li le molemo haholo, li lumellana le lithuto tse fetileng. E 'ngoe ea liphuputso tsa bohlokoa ka ho fetisisa tsa bophelo bo botle ba VMDN-003b le thutong ea mohato oa II ke hore VM202 e ne e sebetsa haholoanyane lithutong tse seng tsa pregabalin kapa gabapentin, e leng meriana e' meli e laetsoeng ka ho fetisisa tšimong ea DPN.

Liphetho tsena li na le litlamorao tsa bohlokoa tsa kliniki kaha batho ba fetang limilione tse 4.2 ba US ba tsejoa ba tšoeroe ke DPN e bohloko 'me bakuli ba ka bang limilione tse 1.3 ba nkoa e le ba hanyetsang, ho bolelang hore meriana e teng hona joale ha e ba sebetse (Painful Diabetic Neuropathy, GlobalData 2018) .

Helixmith e qalile teko ea bobeli ea karolo ea 3 bakeng sa DPN, REGAiN-1A (VMDN-003-2), United States 'me e shebane le tokollo ea liphetho tse holimo qetellong ea 2022. Khampani e rera ho qala karolo ea boraro ea DPN. karolong ea bobeli ea 3.

Lintlha tsa bohlokoa tsa pampiri ea CTS

• VM202 (donaperminogene seltoplasmid) ke mofuta oa pele, o nang le thepa, o se nang kokoana-hloko, o ka 'nang oa tsosolosa DNA ea plasmid ea liphatsa tsa lefutso, ho tloha ponong ea liphoofolo tse seng tsa kliniki.

• Thuto ea Mokhahlelo oa 3 bakeng sa DPN e bohloko e entsoe ka likarolo tse peli, e 'ngoe bakeng sa likhoeli tsa 9 (VMDN-003; lihlooho tse makholo a mahlano) le e' ngoe e nang le katoloso ea likhoeli tsa 3 ho likhoeli tsa 12 (VMDN-003b; lithuto tse 101).

• Polokeho le mamello ea VM202 e tsoela pele ho bonahala e le molemo haholo, e tsamaellana le lithuto tsa pele.

• Liphetho tsena li na le litlamorao tsa bohlokoa tsa kliniki kaha batho ba fetang limilione tse 4.2 ba US ba tsebahala ba tšoeroe ke DPN e bohloko 'me bakuli ba ka bang limilione tse 1.3 ba hanana le hore meriana e teng ha e ba sebetse.

Mabapi le Diabetic Peripheral Neuropathy

Bohloko ba DPN ke bothata bo tloaelehileng le bo fokolisang ba lefu la tsoekere le nang le phello e mpe haholo boleng ba bophelo, boroko le maikutlo. Litlhare tsa morao-rao li kokobetsa bohloko 'me ha li shebane le mekhoa e bakoang ke DPN e bohloko. Ho feta moo, phomolo ea matšoao e atisa ho fokolloa, 'me bakuli ba bangata ba nang le DPN e bohloko ba ntse ba sebelisa li-opioid.

Mabapi le mongoli

Avatar ea Linda Hohnholz

Linda Hohnholz

Mohlophisi e ka sehloohong bakeng sa eTurboNews e thehiloe ho eTN HQ.

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