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Teko ea Tleliniki e Phethahatsa Palo e Lebeletsoeng ea Bakuli bakeng sa Boithuto ka Lefu la Alzheimer

ngotsoeng ke mohlophisi

Synaptogenix, Inc. kajeno e phatlalalitse hore e phethetse ho ngolisa sepheo sa eona sa bakuli ba 100 bakeng sa tlhahlobo ea eona e tsoelang pele ea National Institutes of Health ("NIH") e tšehelitsoeng ke Phase 2b ea kliniki ea Bryostatin-1 bakeng sa bakuli ba nang le lefu la Alzheimer's e tsoetseng pele le e matla haholo ("AD). ”). Khampani e lebelletse ho phatlalatsa lintlha tsa mantlha ho tsoa boithutong nakong ea kotara ea bone ea 2022.

Synaptogenix e boetse e tlaleha hore Boto e ikemetseng ea Data Safety Monitoring Board ("DSMB") e okametseng nyeoe e netefalitse ho ba sieo ha litaba tse amanang le ts'ireletso tse mpe tse amanang le lithethefatsi.

Bryostatin-1 e bakile ntlafatso ea bohlokoa haholo ea kelello (4.0 SIB psychometric score kaholimo ho motheo) bakeng sa bakuli ba boletsoeng esale pele ba amohetseng Bryostatin-1 ha Namenda a le sieo litekong tsa rona tse peli tse fetileng, tse kopaneng tsa likhoeli tse 3, tse sa tsoa hatisoa ho thaka. sengoloa se hlahlobiloeng (JAD, 2022) - athe bakuli ba tšoaroang ka Placebo ba ne ba sa bonts'a molemo o moholo. Phekolo ea Bryostatin-1 e se e atolositsoe ho kenyelletsa palo e habeli ea litekanyetso (N = 14) tekong ea hona joale ea likhoeli tse 6, e laoloang ke placebo, moo ngoliso e sa reroang e laoloang ka hloko bakeng sa metheo e leka-lekaneng ea kalafo le lihlopha tsa placebo. Bakuli ba tla be ba hlokometsoe nako e telele ho feta likhoeli tse tharo ka mor'a hore dosing e khaotse, ho fanoe ka phehello ea melemo bonyane matsatsi a 30 ka mor'a hore dosing e neng e bonoa pele.

"Re khothatsoa ke hore lintlha tsa mantlha tse lokelang ho fanoa kotareng ea bone, 4, li tla bonts'a molemo o tšoanang kapa o moholo o seng o bonoe bakeng sa bakuli ba lihlopha tse tšoanang, tse neng li ile tsa phekoloa pele ho nako litekong tsa rona tsa liteko tsa Phase 2022a tse fetileng. Ho ba sieo ha liketsahalo tse mpe tse amanang le lithethefatsi, joalo ka ha ho hlokometsoe ka maano a mang a seng makae a kalafo a fihletseng tumello e lekanyelitsoeng ea Tsamaiso ea Lijo le Lithethefatsi ("FDA") bakeng sa AD, ho lokela ho re thusa ho latela mehato ea rona ea ts'ebeliso ea bongaka. Melemo ea bonyane lintlha tse 2 tsa SIB, tse kaholimo ho motheo, e kanna ea ba tsa bohlokoa ho tsa bongaka, ka hona li na le monyetla oa ho phekola lefu lena le ho fana ka phomolo ea matšoao," ho boletse Daniel Alkon, MD, Mopresidente oa Khampani le Ofisiri e Moholo ea Saense. .

Alan Tuchman MD, Mookameli e Moholo oa Khampani, o itse, "Bopaki bo ntse bo hōla 'me bo tsoela pele ho tšehetsa Bryostatin-1 e le phekolo e ka bang teng bakeng sa lefu la Alzheimer's. Re thabile kajeno ho phatlalatsa ho phetheloa ha ngoliso ea rona ea Mokhahlelo oa 2b mme re emetse ka tjantjello ho baloa ha lintlha tsa rona tsa mantlha hamorao selemong sena. ”

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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