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Thuto e Ncha ea J&J Booster: 85% E sebetsa Khahlanong le Kokelo ea COVID-19

ngotsoeng ke mohlophisi

Litlhahlobo tse arohaneng li bonts'itse matlafatso ea ente ea Johnson & Johnson COVID-19 e hlahisitse keketseho ea makhetlo a 41 ho li-antibodies le keketseho ea makhetlo a 5 ho T-cell khahlano le Omicron.

Johnson & Johnson kajeno ba phatlalalitse liphetho tse ncha tsa selelekela ho tsoa liphuputsong tsa Afrika Boroa tsa Mokhahlelo oa 3b Sisonke tse bonts'itseng hore sets'oants'o sa ente e tšoanang (ente e tšoanang) ea ente ea Johnson & Johnson COVID-19 (Ad26.COV2.S) e bonts'itse katleho ea 85 lekholong khahlano le COVID- Ho kena sepetlele ho amanang le 19. Boithuto bona, bo entsoeng ke Lekhotla la Lipatlisiso tsa Bongaka la Afrika Boroa (SAMRC), bo bonts'itse hore Johnson & Johnson booster e fokolitse kotsi ea ho kena sepetlele ho tsoa ho COVID-19 har'a basebeletsi ba tsa bophelo bo botle Afrika Boroa kamora hore Omicron e fetohe mofuta o ka sehloohong. Likhoeling tse ithutoang (bohareng ba Pulungoana ho isa bohareng ba Tšitoe) makhetlo a Omicron a eketsehile ho tloha ho liperesente tse 82 ho isa ho tse 98 tsa linyeoe tsa COVID-19 Afrika Boroa joalo ka ha ho tlalehiloe ke GISAID, morero o fanang ka data ea COVID-19.     

Tlhahlobo ea bobeli, e arohaneng ea karabelo ea 'mele ea ho itšireletsa mafung ho mefuta e fapaneng ea ente, e entsoeng ke Beth Israel Deaconess Medical Center (BIDMC), e bonts'itse hore heterologous booster (ente e fapaneng) ea ente ea Johnson & Johnson COVID-19 ho batho ba qalileng ho fumana BNT162b2. Ente ea mRNA e hlahisitse keketseho e menahaneng ea 41 ea likarabo tsa antibody le keketseho ea makhetlo a 5 ho CD8+ T-cell ho Omicron ka libeke tse 'nè ka mor'a ho matlafatsoa. Ho matlafala ha homologous le BNT162b2 ho hlahisitse keketseho ea makhetlo a 17 ho li-antibodies tse fokolang le keketseho ea 1.4 ea lisele tsa CD8 + T ka libeke tse 'nè ka mor'a ho matlafatsa. Ka bobeli li-antibodies le CD8+ T-cell li ne li le holimo libeke tse 'nè ka mor'a ho matlafatsoa ka ente ea Johnson & Johnson ho feta ka ente ea BNT162b2.

Keketseho ea lisele tsa CD8+ T-cell tse hlahisitsoeng ke ente ea Johnson & Johnson e kanna ea ba senotlolo sa ho hlalosa maemo a holimo a katleho khahlano le lefu le matla la COVID-19 le ho kena sepetlele thutong ea Sisonke 2, joalo ka ha mofuta oa Omicron o bonts'itsoe ho phonyoha li-antibodies.

Lintlha li rometsoe ho seva sa pre-print medRxiv ke bangoli ba lithuto, ka tebello ea ho phatlalatsoa likoranteng tse hlahlobiloeng ke lithaka.

Phase 3b Sisonke 2 Booster Shot Study in South African Health Workers

WTM London ea 2022 e tla etsahala ho tloha ka la 7-9 Pulungoana 2022. Ngodisa hona joale!

Lintlha tse tsoang tekong ea Sisonke 2 (n=227,310), e entsoeng har'a basebeletsi ba tsa bophelo bo botle Afrika Boroa ba ileng ba fumana ente e le 'ngoe ea Johnson & Johnson COVID-19 e le tekanyo ea mantlha, e bontša hore matlafatso ea Johnson & Johnson COVID-19 e ekelitse katleho ea ente. (VE) khahlanong le ho kena sepetlele ho ea ho karolo ea 85 lekholong. Ha thunya e matlafatsang e ne e fanoa likhoeli tse tšeletseng ho isa ho tse robong ka mor'a tekanyo e le 'ngoe ea mantlha, VE e ile ea eketseha ha nako e ntse e ea ho tloha ho karolo ea 63 lekholong (95% CI, 31-81%) matsatsing a 0-13, ho ea ho karolo ea 84 lekholong (95% CI, 67-92). %) matsatsing a 14-27 le karolo ea 85 lekholong (95% CI, 54-95%) ka mor'a likhoeli tse 1-2.

Sisonke 2 e ile ea etsoa litsing tse ka bang 350 tsa ente ho pholletsa le liprofinse tse robong tsa Afrika Boroa. Ho sebelisa lintlha tse tsoang ho Discovery Health, mokhatlo oa tlhokomelo ea tlhokomelo ea Afrika Boroa, bafuputsi ba liteko ba fumane VE ea Johnson & Johnson COVID-19 booster shot (n=69,092) ha e bapisoa le batho ba bang ba ngolisitseng mokhatlong o le mong oa tlhokomelo o laoloang, nakong ea ho tloha ka Pulungoana. 15, 2021, ho fihlela ka la 20 Tšitoe, 2021.

Ho ingolisa bakeng sa lekala la Sisonke 2 la teko ho qalile pele ho qaleho ea leqhubu la Omicron Afrika Boroa, ho lumella bafuputsi ho lekola katleho ea ente ea Khampani ea COVID-19 ka ho khetheha kaha Omicron e ile ea fetoha mofuta o hlahelletseng ka har'a naha. Sebopeho sa genomic sa batho ba ikhethileng ho tsoa linyeoeng tsa COVID-19 ha sea etsoa nyeoeng ena.

Basebeletsi ba tsa bophelo bo botle ba na le kotsi e kholo ea ho tšoaetsoa ke COVID-19, 'me linaheng tse kang Afrika Boroa, tse nang le baahi ba bangata ba phelang le li-commorbidities, litlamorao tsa ts'oaetso ea SARS-CoV-2 ho basebeletsi ba tsa bophelo bo botle li tebile haholo. Boholo ba basebeletsi ba tsa bophelo bo botle ba Afrika Boroa ba hlokahetseng ke COVID-19 bonyane ba ne ba e-na le lefu le le leng, 'me ba bangata ba ne ba e-na le maloetse a mangata.

Likarabo tsa Antibody le T-Cell After Heterologous Boosting Regimen E kholo ho feta Ka mor'a Homologous Regimen Khahlanong le Omicron Variant

Tlhahlobo ea batho ba 65 ba fumaneng ente ea mantlha e nang le litekanyetso tse peli tsa ente ea mRNA COVID-19 (BNT162b2), e lateloang ke ente ea homologous booster ea BNT162b2 (n=24) kapa booster ea heterologous e nang le ente ea Johnson & Johnson COVID-19 ( n = 41) kamora bonyane likhoeli tse ts'eletseng, o fumane hore mekhoa ka bobeli e eketsehile karabelo ea bosoasoi le cellular khahlano le Omicron.

Likarabo tsa antibody khahlano le Omicron li matlafalitsoe ke ente ea Johnson & Johnson COVID-19 le ente ea BNT162b2, ha ente ea Johnson & Johnson COVID-19 e ntse e eketsa li-antibody titers ka makhetlo a 41 ka mor'a libeke tse 'ne. Ente ea BNT162b2 e ile ea fumanoa e eketsa li-antibody titers ho ea boemong bo phahameng ka beke ea bobeli ka mor'a matlafatso, pele e hana ho emela keketseho ea makhetlo a 17 ka beke ea bone ka mor'a ho matlafatsa. Keketseho e tsoelang pele ea li-antibodies libeke tse latelang ho entoa ha Johnson & Johnson booster e tšoana le e bonoang ka mor'a ente ea pele. Karabelo e potlakileng ea 'mele ea ho itšireletsa mafung e lateloang ke phokotseho ea karabelo ea antibody ka mor'a hore BNT162b2 booster e ts'oana le e bonoang kamora mokhoa oa ho qala oa litekanyetso tse peli.

Ente ea Johnson & Johnson COVID-19 e matlafalitse lisele tse bohareng tsa Omicron-reactive CD8+ T-cell ka 5.5-fold, le Omicron-reactive CD4+ T-cells ka makhetlo a 3.1, ha mofuta oa homologous (BNT162b2) o matlafalitse CD4+ le CD8+ tsa Omicron-reactive. T-lisele ka makhetlo a 1.4.

Li-T-cell li ka lebisa le ho senya lisele tse tšoaelitsoeng ke vaerase e bakang COVID-19 mme ho lumeloa hore li kenya letsoho ts'ireletso khahlanong le lefu le matla. Haholo-holo, li-CD8+ T-cell li ka senya lisele tse tšoaelitsoeng ka kotloloho 'me li thusoa ke CD4+ T-cell.

Lintlha tsena li fana ka maikutlo a hore heterologous boosting e na le monyetla oa ho susumetsa boits'ireletso bo matla ba lisele, bo bohlokoa bakeng sa mohopolo oa 'mele oa ho itšireletsa mafung le ts'ireletso khahlanong le lefu le matla le tlase la phefumoloho. Ho tšoarella ha li-heterologous le homologous boost regimens bakeng sa mofuta oa SARS-CoV-2 Omicron ho sa ntse ho tla etsoa qeto.

Tlhahisoleseling e 'Ngoe

Ente ea Johnson & Johnson COVID-19 e lumelletsoe e le matlafatso ke balaoli ba bangata le mekhatlo ea tlhokomelo ea bophelo lefatšeng ka bophara. Johnson & Johnson ba ntse ba tsoela pele ho fana ka lintlha tse amehang ho balaoli ba bang, Mokhatlo oa Lefatše oa Bophelo (WHO) le Lihlopheng tsa Naha tsa Boeletsi ba Ente ea Sechaba (NITAGs) lefatšeng ka bophara ho tsebisa ho etsoa liqeto mabapi le maano a tsamaiso ea ente ea lehae, ha ho hlokahala.

Ka la 16 Tšitoe 2021, Litsi tsa US tsa Taolo le Thibelo ea Mafu (CDC) li khothalelitse likhothaletso tse nchafalitsoeng tse entsoeng ke Komiti ea Boeletsi ea Mekhoa ea Ente (ACIP) bakeng sa thibelo ea COVID-19, e bonts'a khetho ea bongaka ea hore batho ba fumane mRNA COVID. -19 ente holim'a ente ea Johnson & Johnsons COVID-19. Naheng ea Amerika, batho ba sa khoneng kapa ba sa batleng ho fumana ente ea mRNA ba tla tsoelapele ho fumana ente ea Johnson & Johnson COVID-19.

Ente ea Johnson & Johnson COVID-19 ke khetho ea bohlokoa bakeng sa batho ba sa khoneng kapa ba ke keng ba khutla bakeng sa liente tse ngata kapa ba tla lula ba sa entoa ntle le mofuta o mong oa ente ea mRNA. Ente ea Johnson & Johnson COVID-19 e hokahana le likhothaletso tsa Mokhatlo oa Lefatše oa Bophelo (WHO) bakeng sa ho kenella litabeng tsa bongaka maemong a seoa, a totobatsang boiketlo ba kabo, tsamaiso le boikamahanyo.

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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