TŠOHLOA
Phetisetso e phahameng ea SARS-CoV-2 e ntse e etsahala Chile leha ho na le lets'olo le matla la ente, leo haholo-holo le itšetlehileng ka ente e sa sebetseng ea kokoana-hloko e tsoang ho Sinovac Biotech le ho isa tekanyong e nyane ho ente ea mRNA e tsoang ho Pfizer/BioNTech le liente tsa vector tse sa replicative tse tsoang. Oxford/AstraZeneca le Cansino Biologicals.
Ts'ebetso ea ho qetela e tlalehiloeng ka har'a naha e laoloa ke mefuta e fapaneng ea SARS-CoV-2 Gamma le Lambda, eo pele e neng e khetholloa e le mofuta o mong oa matšoenyeho likhoeling tse 'maloa tse fetileng mme ea morao tjena e amohetsoe e le mofuta o fapaneng oa thahasello ke WHO. Le ha mofuta oa Gamma o na le liphetoho tse 11 protheineng ea spike ho kenyelletsa le tse sebakeng sa receptor-binding (RBD) tse amanang le ho eketseha ha ACE2 tlamang le ts'oaetso (N501Y) kapa ho phonyoha ha 'mele (K417T le E484K) protheine ea spike ea mofuta oa Lambda e na le mofuta o ikhethileng. mohlala oa liphetoho tse 7 (Δ246-252, G75V, T76I, L452Q, F490S, D614G, T859N) eo L452Q e ts'oanang le phetoho ea L452R e tlalehiloeng ka mefuta e fapaneng ea Delta le Epsilon.
Phetoho ea L452R e bonts'itsoe hore e fana ka phonyoho ea 'mele ho li-monoclonal antibodies (mAbs) hammoho le plasma ea convalescent.
Ho feta moo, phetoho ea L452R e boetse e bontšitsoe ho eketsa tšoaetso ea kokoana-hloko 'me lintlha tsa rona li fana ka maikutlo a hore phetoho ea L452Q e teng ka har'a mofuta oa Lambda e ka fana ka thepa e tšoanang le e hlalositsoeng bakeng sa L452R. Ho khahlisang, ho hlakoloa ha 246-252 sebakeng sa N-terminal (NTD) ea Lambda Spike e sebakeng sa supersite ea antigenic, ka hona, ho hlakoloa hona ho ka kenya letsoho ho phonyoha ha 'mele. Ho feta moo, phetoho ea F490S e boetse e amahanngoa le ho balehela ho sera sa convalescent.
Tumellanong le li-antecenters tsena, liphetho tsa rona li bonts'a hore protheine ea spike ea mofuta oa Lambda e fana ka phonyoha ea 'mele ho li-antibodies tse hlahisoang ke ente ea CoronaVac. Hore na mofuta oa Lambda le ona o balehela karabelong ea cellular e bontšitsoeng hore e khothalelitsoe ke CoronaVac ha e so tsejoe.
Re boetse re hlokometse hore protheine ea spike ea mofuta oa Lambda e hlahisitse ts'oaetso e eketsehileng ha e bapisoa le protheine ea spike ea mefuta e fapaneng ea Alpha le Gamma, ka bobeli ba na le ts'oaetso e ntseng e eketseha le phetisetso.
Ka kopanelo, datha ea rona e bonts'a lekhetlo la pele hore liphetoho tse teng ka har'a protheine ea spike ea mofuta oa Lambda li fana ka phonyoha ho li-antibodies tse fokotsang ts'oaetso le ts'oaetso e eketsehileng. Bopaki bo hlahisitsoeng mona bo tiisa mohopolo oa hore matšolo a maholo a ente linaheng tse nang le litekanyetso tse phahameng tsa phepelo ea SARS-CoV-2 a tlameha ho tsamaea le tlhahlobo e tiileng ea genomic e reretsoeng ho tsebahatsa libaka tse ncha tsa vaerase tse nang le liphetoho tsa spike hammoho le lithuto tse reretsoeng ho sekaseka phello ea tsena. liphetoho tsa ho phonyoha ha 'mele oa ho itšireletsa mafung le katleho ea liente.
COVID-19 e ntse e tsoela pele ka potlako. Sena se ka bonoa Hawaii moo lipalo li neng li le tlase 'me tsa tlola ho rekota holimo ka bohahlauli bo ntseng bo eketseha.
