Entrinsic Bioscience le laesense ea eona ea Nuvara Therapeutics ba phatlalalitse hore ba mohato o le mong o haufi le ho sebelisa litlhare tsa RxAA joalo ka kalafo ho bakuli ba nang le liphetoho tsa Cystic Fibrosis Class I. Mofuputsi oa Univesithi ea Florida Dr. Sadasivan Vidyasagar, mothehi le molula-setulo oa boto ea boeletsi ba saense ea k'hamphani, haufinyane o ile a arolelana mokhoa o mong oa ho tsosolosa secretion ea anion ea airway kopanong ea Experimental Biology 2022 e neng e tšoaretsoe Philadelphia.
Vidyasagar le sehlopha sa hae, se neng se kenyelletsa bafuputsi ba UF le Entrinsic Bioscience, ba bontšitse hore foromo ea Nuvara's VS-009 e ka ba molemo ho bakuli ba nang le liphetoho tsa Cystic Fibrosis Class I hammoho le Class II le III. Kalafo e ka sebelisoa e le mong kapa e kopane le litlhare tse ling ho ntlafatsa secretion ea chloride.
Stephen J. Gatto, Molula-setulo ea Phethahatso oa Nuvara Therapeutics, o ile a thoholetsa Astrid Grosche le sehlopha sa Dr. Vidyasagar ka boitlamo ba bona bo tsoelang pele ba ho khanna mekhoa e mecha ea ho hlahloba mosebetsi oa epithelial ea ho hema.
"Ke batla ho leboha Astrid, Dr. Vidyasagar le sehlopha sa hae kaofela ka boitlamo ba bona bo sa khathaleng ba ho rarolla liphetoho tsa Class I ho Cystic Fibrosis, phetoho e ka amang ho fihlela ho 18% ea baahi ba CF," ho boletse Stephen J. Gatto.
"Likaroloana tsena tse peli li bonts'a hore ho qhekella ha ion-channel ho ka khoneha ho epithelium ea phefumoloho ho sebelisoa metsoako e hlophisitsoeng ea li-amino acid," Gatto a tsoela pele. "Ho se sebetse ha ion-channel ho bohareng ba mafu a mangata, a kang CF le mafu ao ho 'ona ho nang le tlhahiso e eketsehileng ea mucous, ho akarelletsa le asthma le COPD. Mekhoa ena / litlhare li tla re lumella ho fetola phallo ea li-ion le metsi ho kena moeeng sebakeng sa lisele tse nang le litla-morao tse fokolang.
"Ho sa ntse ho e-na le mosebetsi o lokelang ho etsoa, empa monyetla ona oa thabisa e le kannete 'me o ka emela katleho tsamaisong ea li-channelopathies le mafu a amanang le ona," ho boletse Gatto.
Vidyasagar o boetse a fana ka sets'oants'o sa sesebelisoa sa laboratori ea hae e ntlafalitsoeng ho lekanya peristalsis ea mala hantle le tšebelisano ea khatello ea intraluminal, ho honyela ha mesifa le liphetoho tsa molumo oa mokelikeli.
"Litlhaloso tsena tse peli li ikhetha ka hore li bontša bokhoni ba ho fetola liprotheine tsa epithelial transmembrane (eTMPs) ka mokhoa o khethiloeng oa amino SAA (RxAAs)," ho boletse Dr. William Denman, Moeletsi ea ka Sehloohong oa Bongaka ho Nuvara Therapeutics. "Sena se bula monyetla oa kalafo e sebetsang hantle, e seng chefo maemong a mantlha a liselefouno, ho sa tsotelehe hore na etiology ke efe."
Dr. Denman o ile a tsoela pele, "Liphekolo tsa kamoso joale li ka khethoa le ho lokisetsoa mocha le lefu - meriana ea 'nete e etselitsoeng motho ka mong. Ho hlokahala mosebetsi o mongata, empa sena se ka lumella mekhoa e meng ea phekolo maemong a cellular ho pholletsa le mafu a nang le litlamorao tse fokolang. ”
Entrinsic Bioscience ke qalo ea UF e fumanehang ho UF Innovate | Potlakisa ho Sid Martin Biotech e Alachua. Khampani e nts'etsapele litlhare tsohle tsa tlhaho, tse se nang tsoekere bakeng sa hydration ea bongaka, bophelo bo botle ba mala le bophelo bo botle, ho kula le tlhokomelo ea letlalo.
SEO U LOKELANG HO SE NKA HO SEHLOOHO ENA:
- Vidyasagar and the rest of his team for their tireless commitment to solve for Class I mutations in Cystic Fibrosis, a mutation which can affect up to 18% of CF population,”.
- “There is still work to be done, but the opportunity is truly exciting and could represent a breakthrough in the management of channelopathies and related diseases,”.
- Vidyasagar o boetse a fana ka sets'oants'o sa sesebelisoa sa laboratori ea hae e ntlafalitsoeng ho lekanya peristalsis ea mala hantle le tšebelisano ea khatello ea intraluminal, ho honyela ha mesifa le liphetoho tsa molumo oa mokelikeli.
