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Lintlha tse Ncha tsa ho Hlasela Kankere ka ho Reprogramming ea Immune

ngotsoeng ke mohlophisi

Kajeno Myeloid Therapeutics, Inc. kajeno e hlahisitse lintlha tse ncha tsa morao-rao Sebokeng sa Selemo sa Selemo sa Mokhatlo oa Amerika oa Patlisiso ea Kankere (AACR), se neng se tšoaretsoe New Orleans, LA, Mmesa 8-13, 2022.             

Lintlha tse hlahisitsoeng ho AACR 2022 li bontša hore Myeloid e thehile le ho nts'etsapele liforomo tse peli tse ncha tsa kalafo, li-receptor tsa ATAK™ CAR le lenaneong la vivo mRNA, ho shebisa le ho kenya tšebetsong bokhoni ba lisele tsa myeloid ho hlasela mofetše ka boits'ireletso ba mmele. Lisele tsa Myeloid ke sehlopha sa mantlha sa karabelo ea 'mele ea ho itšireletsa mafung 'me li bokellana ka tlhaho ka har'a lihlahala tse tiileng, maemong a mang li emela liperesente tse mashome a supileng a metso e mehlano tsa boima ba hlahala. Liphetoho tsa Myeloid tsa mRNA bakeng sa phaposi ea myeloid li holisa tšusumetso ea lisele tsena ka har'a liteko tsa vivo.

Sehlopha se secha sa Myeloid sa li-CAR, se tsejoang ka hore ke ATAK™ Receptors, se kopanya temoho ea hlahala le libaka tse ngata tsa mats'oao tsa innate-immune. Bo-ramahlale ba Myeloid ba hlahlobile metsoako e mengata e sa lekoeng ea matšoao a ka hare a 'mele oa ho itšireletsa mafung 'me ba sibolla litsela tse nepahetseng tsa matšoao a mangata. Motsoako oa likhokahano tsa tlhokomeliso ea mofets'e le libaka tsena tse ncha tsa matšoao a intracellular li lumella lisele tsa myeloid hore li hlophisoe ka motsoako oa pele oa matšoao a 'mele oa ho itšireletsa mafung, o lebisang polaong ea tumor le likarabelo tse pharalletseng tsa anti-tumor.

Pale ea Myeloid ho sethaleng sa boenjiniere ba vivo e shebisisa ka ho khetheha le ho kenya tšebetsong lisele tsa myeloid ho hlahisa boits'ireletso bo matla ba anti-tumor. Ka mokhoa ona, Myeloid e bonts'a hore phano ea lipid-nanoparticles (LNPs) e koahelang mRNA e fella ka ho amoheloa le ho hlahisa maikutlo ka lisele tsa myeloid ka har'a vivo, e leng se lebisang polaong e matla ea hlahala mefuteng e mengata e batang ea hlahala. Lintlha tsena li bonts'a bokhoni ba theknoloji ea Myeloid ea ho hlophisa lisele ka kotloloho ho vivo.

"Sebokeng sa AACR sa selemo sena, re thabetse ho hlahisa tsoelo-pele e kholo ho li-platform tsa rona tse bonts'ang bokhoni ba lisele tsa myeloid ho hlophisa likarabo tse pharaletseng tsa 'mele oa ho itšireletsa mafung ka lenaneo la vivo mRNA le moloko o latelang oa ATAK™ CARs," ho boletse Bruce McCreedy, Ph. D., Ofisiri e ka Sehloohong ea Saense ea Myeloid. "Lintlha tsena li tšehetsa merero ea rona ea ho qala liteko tsa tleliniki ho lekola polokeho le ts'ebetso ea batho ba 'maloa ba sehlahiswa sa lithethefatsi nakong ea selemo se tlang, ho holisa lipeipi tsa rona tsa bongaka tse teng."

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mohlophisi

Mohlophisi e moholo oa eTurboNew ke Linda Hohnholz. O lula ntlong e kholo ea eTN e Honolulu, Hawaii.

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